Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• all mice die before 20 days postnatal; most die within 1 week
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growth/size/body
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• mice do not gain weight after birth; mice surviving ~3 weeks show decreased body weight relative to littermates
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vision/eye
integument
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• delay in hair growth is observed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• only 50% of mice survive to adulthood
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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growth/size/body
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• mice appear normal but body weight is slightly decreased by 25% compared to littermates
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behavior/neurological
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• when given a new learning test following the retention test, mice show a deficit in transfer of learning capacity to a new situation compared to controls
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• when retested 31 days after initial training period, mice do not retain level of performance initial acquired with learning
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• in a radial maze test, mice show working memory errors
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• mice show marked impairment in coordination and fatigability assessed by the rotarod test
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• adult mice show abnormal hind limb position when walking or suspended by tail
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• adults display waddling gait due to abnormal hind limb position; mice walk on tiptoes of hind feet
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• adult transgenic mice show increased latency in hot plate test
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nervous system
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• majority of neurons in lumbar DRG have pyknotic nuclei
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• innervating fibers in the spleen are scattered throughout germinal center and marginal zone, without reaching the central artery
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• cells are greatly reduced in size (157-193 um2 vs 218-311 um2 in controls) at 2 months
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• markedly smaller at 2 months of age compared to controls
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• extent of CA3 mossy fibers is markedly reduced at 2 months
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• number of choline acetyl transferase ChAT neurons in basal forebrain and hippocampus is reduced in adult animals relative to controls
• cell bodies of ChAT-positive fibers projecting to cortex and hippocampus show marked shrinkage
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• neuron size with respect to cell body size is dramatically reduced with median size of 425 um2 in controls vs 75 um2 in transgenic mice at 2 months
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muscle
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• fibers show an irregular shape
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• fibers show a decreased cross-sectional area
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• at 2 months, significant reduction of the mass (atrophy) of longitudinal dorsal muscles and the flexor and abducent muscles of the hind limbs is observed in adults, but not in mice 2-30 days postnatal
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hematopoietic system
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• transgenic mice have 3-fold more apoptotic cells in the spleen compared to controls
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• in adults, number of viable splenocytes in transgenic spleens is dramatically lower than in controls; proportion of IgG-positive cells is reduced while IgD-positive cells are slightly increased
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immune system
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• transgenic mice have 3-fold more apoptotic cells in the spleen compared to controls
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• in adults, number of viable splenocytes in transgenic spleens is dramatically lower than in controls; proportion of IgG-positive cells is reduced while IgD-positive cells are slightly increased
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skeleton
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• mice often develop scoliosis of the back
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cellular
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• majority of neurons in lumbar DRG have pyknotic nuclei
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• transgenic mice have 3-fold more apoptotic cells in the spleen compared to controls
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homeostasis/metabolism
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