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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr96tm2Litt
targeted mutation 2, Dan R Littman
MGI:2446611
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr96tm2Litt/Rr96tm2Litt involves: 129P2/OlaHsd MGI:3716323
cx2
 		Rr96tm2Litt/Rr96+
Zbtb7btm1.1Tani/Zbtb7btm1.1Tani 		involves: 129 * 129P2/OlaHsd * C57BL/6 MGI:3817577
cx3
 		Rr96tm2Litt/Rr96+
Zbtb7btm1Itan/Zbtb7btm1.1Tani 		involves: 129 * 129P2/OlaHsd * C57BL/6 MGI:3817581
cx4
 		Rr96tm2Litt/Rr96tm2Litt
Tfap4tm1.1Litt/Tfap4tm1.1Litt 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:5296824


Genotype
MGI:3716323
hm1
Allelic
Composition		 Rr96tm2Litt/Rr96tm2Litt
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD8-positive, alpha beta T cell morphology ( J:80690 )
• CD4 expression is derepressed in CD8+ cells

hematopoietic system
abnormal CD8-positive, alpha beta T cell morphology ( J:80690 )
• CD4 expression is derepressed in CD8+ cells




Genotype
MGI:3817577
cx2
Allelic
Composition		 Rr96tm2Litt/Rr96+
Zbtb7btm1.1Tani/Zbtb7btm1.1Tani
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr96tm2Litt mutation (0 available); any Rr96 mutation (0 available)
Zbtb7btm1.1Tani mutation (1 available); any Zbtb7b mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased double-negative T cell number ( J:141142 )
• virtually all T cells found in the lymph node are double-positive T cells

immune system
increased double-negative T cell number ( J:141142 )
• virtually all T cells found in the lymph node are double-positive T cells




Genotype
MGI:3817581
cx3
Allelic
Composition		 Rr96tm2Litt/Rr96+
Zbtb7btm1Itan/Zbtb7btm1.1Tani
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr96tm2Litt mutation (0 available); any Rr96 mutation (0 available)
Zbtb7btm1.1Tani mutation (1 available); any Zbtb7b mutation (26 available)
Zbtb7btm1Itan mutation (0 available); any Zbtb7b mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal double-negative T cell morphology ( J:141142 )
• the increase in double negative T cells observed in Zbtb7btm1Itan / Zbtb7btm1Tani compound heterozygotes is not observed in these mice
decreased CD8-positive, alpha-beta T cell number ( J:141142 )
• CD8+ T cells are almost absent in the periphery

hematopoietic system
abnormal double-negative T cell morphology ( J:141142 )
• the increase in double negative T cells observed in Zbtb7btm1Itan / Zbtb7btm1Tani compound heterozygotes is not observed in these mice
decreased CD8-positive, alpha-beta T cell number ( J:141142 )
• CD8+ T cells are almost absent in the periphery




Genotype
MGI:5296824
cx4
Allelic
Composition		 Rr96tm2Litt/Rr96tm2Litt
Tfap4tm1.1Litt/Tfap4tm1.1Litt
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr96tm2Litt mutation (0 available); any Rr96 mutation (0 available)
Tfap4tm1.1Litt mutation (0 available); any Tfap4 mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:176461 )
• in vivo, Cd4 silencing in immature thymocytes and effector/memory CD8+ T cells is impaired
• however, in vitro Cd4 silencing in activated CD8+ T cells is normal

immune system
abnormal T cell differentiation ( J:176461 )
• in vivo, Cd4 silencing in immature thymocytes and effector/memory CD8+ T cells is impaired
• however, in vitro Cd4 silencing in activated CD8+ T cells is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory