Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkc1tm1Bsl mutation
(0 available);
any
Dkc1 mutation
(3 available)
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normal phenotype
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• mice are viable and fertile and indistinguishable from wild-type littermates
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkc1tm1Bsl mutation
(0 available);
any
Dkc1 mutation
(3 available)
Tg(Gata1-cre)1Sho mutation
(2 available)
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mortality/aging
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• no male embryos are recovered at E7.5 when the mutant allele is derived maternally
• same phenotype is observed when EIIa-cre transgenic males are used
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkc1tm1Bsl mutation
(0 available);
any
Dkc1 mutation
(3 available)
Tg(Gata1-cre)1Sho mutation
(2 available)
|
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mortality/aging
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• no live embryos are recovered at E9.5 and most have been resorbed at E12.5, with inheritance of the maternally derived mutant allele
• same phenotype is observed when EIIa-cre transgenic males are used
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embryo
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• after E7.5, apoptotic nuclei are observed in the trophectoderm
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• at E8.5 and E9.5, embryos appear morphologically disorganized relative to wild-type
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• at E8.5 or E9.5, embryos do not show signs of axial rotation
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• after E7.5, embryos become developmentally growth arrested
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• at E8.5 and E9.5, embryos are visibly smaller than littermates
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• at E8.5 and E9.5, degeneration within the trophectoderm becomes more extensive
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growth/size/body
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• at E8.5 and E9.5, embryos are visibly smaller than littermates
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reproductive system
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• females with the deletion on the paternally-inherited allele are unable to transmit the deletion to offspring; only homozygous Dkc1+, cre transgene-negative male and female offspring are obtained when females heterozygous for the deleted allele are crossed to wild-type males
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cellular
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• after E7.5, apoptotic nuclei are observed in the trophectoderm
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Allelic Composition |
Dkc1tm1Bsl/Y
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Genetic Background |
involves: 129/Sv * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkc1tm1Bsl mutation
(0 available);
any
Dkc1 mutation
(3 available)
|
|
|
normal phenotype
|
• mice are viable and fertile and indistinguishable from wild-type littermates
|