Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fyntm1Sor mutation
(3 available);
any
Fyn mutation
(37 available)
Tg(Camk2a-Fyn-531)1Nko mutation
(1 available)
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mortality/aging
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• sudden death after weaning; survival rate shows correlation with level of transgene expression
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behavior/neurological
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• lines expressing high levels of the transgene show spontaneous running and bouncing fits
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nervous system
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-Fyn-531)1Nko mutation
(1 available)
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behavior/neurological
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• 40% reduction in voluntary alcohol intake
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• exhibit resistance against alcohol withdrawal-induced behavior; whereas wild-type show reduced exploration of the light compartment and fewer transitions between light and dark after alcohol discontinuation, mutants show normal exploratory behavior, similar to that seen in non-alcohol treated wild-type mice
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• exhibit resistance against alcohol withdrawal-induced behavior; whereas wild-type show reduced exploration of the light compartment and fewer transitions between light and dark after alcohol discontinuation, mutants show normal exploratory behavior, similar to that seen in non-alcohol treated wild-type mice
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• following alcohol withdrawal, mutants do not show the pronounced anxiety-like behavior seen in wild-type controls
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• following alcohol withdrawal, mutant mice show unaltered exploratory behavior in light/dark box test, unlike wild-type that show decreased locomotor activity
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-Fyn-531)1Nko mutation
(1 available)
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mortality/aging
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• sudden death after weaning; survival rate shows correlation with level of transgene expression
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behavior/neurological
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• reduced penthylenetetrazole dosage required for tonic extension
• reduced lethal penthylenetetrazole dosage
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• lines expressing high levels of the transgene show spontaneous running and bouncing fits
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• increased seizure activity in response to once-daily electrical stimution of the amygdala
• prolonged after discharge (greater than 30 seconds) is often observed
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• exhibit accelerated kindling in response to once-daily stimulation of the amygdala
• kindling is repressed by MK-108 administration
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• tonic convulsion; seizure severity shows correlation with level of transgene expression
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nervous system
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• reduced penthylenetetrazole dosage required for tonic extension
• reduced lethal penthylenetetrazole dosage
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• increased seizure activity in response to once-daily electrical stimution of the amygdala
• prolonged after discharge (greater than 30 seconds) is often observed
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• exhibit accelerated kindling in response to once-daily stimulation of the amygdala
• kindling is repressed by MK-108 administration
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• tonic convulsion; seizure severity shows correlation with level of transgene expression
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Analysis Tools