Phenotypes associated with this allele

• Allele Symbol: Tg(Camk2a-Fyn-531)1Nko
• Allele Name: transgene insertion 1, Nobuhiko Kojima
• Allele ID: MGI:2446470
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Fyn^tm1Sor/Fyn^+ Tg(Camk2a-Fyn-531)1Nko/0	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:2652121
tg2	Tg(Camk2a-Fyn-531)1Nko/0	B6.Cg-Tg(Camk2a-Fyn-531)1Nko	MGI:3693333
tg3	Tg(Camk2a-Fyn-531)1Nko/0	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:2652119

Genotype
MGI:2652121

cx1

• Allelic Composition: Fyn^tm1Sor/Fyn⁺; Tg(Camk2a-Fyn-531)1Nko/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:59490 )

• sudden death after weaning; survival rate shows correlation with level of transgene expression

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:59490 )

• lines expressing high levels of the transgene show spontaneous running and bouncing fits

tonic seizures ( J:59490 )

• tonic convulsion

nervous system

tonic seizures ( J:59490 )

• tonic convulsion

Genotype
MGI:3693333

tg2

• Allelic Composition: Tg(Camk2a-Fyn-531)1Nko/0
• Genetic Background: B6.Cg-Tg(Camk2a-Fyn-531)1Nko

behavior/neurological

alcohol aversion ( J:79980 )

• 40% reduction in voluntary alcohol intake

impaired behavioral response to alcohol ( J:79980 )

• exhibit resistance against alcohol withdrawal-induced behavior; whereas wild-type show reduced exploration of the light compartment and fewer transitions between light and dark after alcohol discontinuation, mutants show normal exploratory behavior, similar to that seen in non-alcohol treated wild-type mice

decreased behavioral withdrawal response ( J:79980 )

• exhibit resistance against alcohol withdrawal-induced behavior; whereas wild-type show reduced exploration of the light compartment and fewer transitions between light and dark after alcohol discontinuation, mutants show normal exploratory behavior, similar to that seen in non-alcohol treated wild-type mice

decreased anxiety-related response ( J:79980 )

• following alcohol withdrawal, mutants do not show the pronounced anxiety-like behavior seen in wild-type controls

abnormal locomotor behavior ( J:79980 )

• following alcohol withdrawal, mutant mice show unaltered exploratory behavior in light/dark box test, unlike wild-type that show decreased locomotor activity

Genotype
MGI:2652119

tg3

• Allelic Composition: Tg(Camk2a-Fyn-531)1Nko/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

mortality/aging

premature death ( J:59490 )

• sudden death after weaning; survival rate shows correlation with level of transgene expression

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:59490 )

• reduced penthylenetetrazole dosage required for tonic extension

• reduced lethal penthylenetetrazole dosage

abnormal motor capabilities/coordination/movement ( J:59490 )

• lines expressing high levels of the transgene show spontaneous running and bouncing fits

abnormal seizure response to electrical stimulation ( J:59490 )

• increased seizure activity in response to once-daily electrical stimution of the amygdala

• prolonged after discharge (greater than 30 seconds) is often observed

abnormal kindling response ( J:59490 )

• exhibit accelerated kindling in response to once-daily stimulation of the amygdala

• kindling is repressed by MK-108 administration

tonic seizures ( J:59490 )

• tonic convulsion; seizure severity shows correlation with level of transgene expression

nervous system

increased susceptibility to pharmacologically induced seizures ( J:59490 )

• reduced penthylenetetrazole dosage required for tonic extension

• reduced lethal penthylenetetrazole dosage

abnormal seizure response to electrical stimulation ( J:59490 )

• increased seizure activity in response to once-daily electrical stimution of the amygdala

• prolonged after discharge (greater than 30 seconds) is often observed

abnormal kindling response ( J:59490 )

• exhibit accelerated kindling in response to once-daily stimulation of the amygdala

• kindling is repressed by MK-108 administration

tonic seizures ( J:59490 )

• tonic convulsion; seizure severity shows correlation with level of transgene expression