Phenotypes associated with this allele

• Allele Symbol: Crkl^tm1Hkp
• Allele Name: targeted mutation 1, Nora Heisterkamp
• Allele ID: MGI:2446094
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crkl^tm1Hkp/Crkl^tm1Hkp	involves: 129S1/Sv * 129X1/SvJ	MGI:3723287
hm2	Crkl^tm1Hkp/Crkl^tm1Hkp	involves: 129S1/Sv * 129X1/SvJ * Black Swiss	MGI:3723283
cx3	Crkl^tm1Hkp/Crkl^tm1Hkp Tg(BCR/ABL)623Hkp/?	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * CBA	MGI:3723274

Genotype
MGI:3723287

hm1

• Allelic Composition: Crkl^tm1Hkp/Crkl^tm1Hkp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:76680 )

• Background Sensitivity: die during embryogenesis unlike on a Black Swiss background in which mutants are viable

embryo

abnormal placenta morphology ( J:76680 )

• placental defects

cardiovascular system

abnormal heart morphology ( J:76680 )

• heart defects

liver/biliary system

abnormal liver morphology ( J:76680 )

• liver defects

Genotype
MGI:3723283

hm2

• Allelic Composition: Crkl^tm1Hkp/Crkl^tm1Hkp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

mortality/aging

postnatal lethality, incomplete penetrance ( J:76680 )

• Background Sensitivity: mutants with decreased birth weight have an increased chance of dying within the first 4 days of life, however those that survive are viable and fertile unlike mutants on a 129/Sv background which die during embryogenesis

growth/size/body

decreased body weight ( J:76680 )

• lower birth weight, however surviving mutants reach the same weight and size by 6 months of age

cardiovascular system

ventricular septal defect ( J:76680 )

• some mutants have a small septum defect in the heart

limbs/digits/tail

abnormal caudal vertebrae morphology ( J:76680 )

• tail vertebra show an irregular, wedge-like shape and the lateral borders are fused to each other on one side, resulting in kinks

kinked tail ( J:76680 )

• 53% of pups at birth have bent or curved tails

skeleton

abnormal caudal vertebrae morphology ( J:76680 )

• tail vertebra show an irregular, wedge-like shape and the lateral borders are fused to each other on one side, resulting in kinks

Genotype
MGI:3723274

cx3

• Allelic Composition: Crkl^tm1Hkp/Crkl^tm1Hkp; Tg(BCR/ABL)623Hkp/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * CBA

mortality/aging

premature death ( J:76680 )

• average survival is 158 days

perinatal lethality, incomplete penetrance ( J:76680 )

• incomplete penetrance

neoplasm

increased leukemia incidence ( J:76680 )

• develop B-lineage leukemia to the same extent as mice expressing the transgene alone

increased B cell derived lymphoma incidence ( J:76680 )

• develop B-lineage lymphoma to the same extent as mice expressing the transgene alone