Phenotypes associated with this allele

• Allele Symbol: Ripk2^tm1Ghc
• Allele Name: targeted mutation 1, Genhong Cheng
• Allele ID: MGI:2446070
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ripk2^tm1Ghc/Ripk2^tm1Ghc	involves: 129S4/SvJae * C57BL/6	MGI:3029954

Genotype
MGI:3029954

hm1

• Allelic Composition: Ripk2^tm1Ghc/Ripk2^tm1Ghc
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:75401 )

• cell proliferation reduced generally although T helper 2 cell proliferation unaffected

decreased IgG2a level ( J:75401 )

• although IgG1 levels were normal, IgG2a levels were 20 fold lower than expected

decreased interferon-gamma secretion ( J:75401 )

• IFN-gamma production by T helper 1 cells reduced

• no increased IFN-gamma production after Il12 stimulation of T helper 1 cells

increased susceptibility to infection ( J:75401 )

hematopoietic system

decreased T cell proliferation ( J:75401 )

• cell proliferation reduced generally although T helper 2 cell proliferation unaffected

decreased IgG2a level ( J:75401 )

• although IgG1 levels were normal, IgG2a levels were 20 fold lower than expected

cellular

decreased T cell proliferation ( J:75401 )

• cell proliferation reduced generally although T helper 2 cell proliferation unaffected