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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		KitlSl-22R
steel 22 Oak Ridge
MGI:2445944
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		KitlSl-22R/KitlSl-22R C3H-KitlSl-22R MGI:3794419
ht2
 		KitlSl-22R/Kitl+ C3H-KitlSl-22R MGI:3794420


Genotype
MGI:3794419
hm1
Allelic
Composition		 KitlSl-22R/KitlSl-22R
Genetic
Background		 C3H-KitlSl-22R
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl-22R mutation (0 available); any Kitl mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:79293 )
• only 61-71% of expected numbers are observed at P1
postnatal lethality, complete penetrance ( J:79293 )
• no animals survive beyond P18

reproductive system
decreased primordial germ cell number ( J:115437 )
• primordial germ cells are severely reduced in number or absent compared to wild-type in genital ridges at E11.5

hematopoietic system
macrocytic anemia ( J:79293 )
• severe at birth
low mean erythrocyte cell number ( J:79293 )
• significantly lower than wild-type at birth (20% of wild-type value)

cellular
decreased primordial germ cell number ( J:115437 )
• primordial germ cells are severely reduced in number or absent compared to wild-type in genital ridges at E11.5




Genotype
MGI:3794420
ht2
Allelic
Composition		 KitlSl-22R/Kitl+
Genetic
Background		 C3H-KitlSl-22R
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitlSl-22R mutation (0 available); any Kitl mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:79293 )
N
• at P1, mean red blood cell (RBC) counts are not different from wild-type mean (4.1 x 109 cells/ml)
macrocytic anemia ( J:79293 )
• mild at birth
increased mean corpuscular hemoglobin ( J:79293 )
• significantly increased compared to wild-type at P24-25
increased mean corpuscular volume ( J:79293 )
• significantly increased compared to wild-type at P24-25

pigmentation

integument




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory