Analysis Tools
nervous system
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• mutants exhibit misoriented, even inverted, apical dendrites in layer V pyramidal neurons in the somatosensory and visual cortices and misoriented dendrites in the motor cortex
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Allele Symbol Allele Name Allele ID |
Ptpratm1Cjp targeted mutation 1, Catherine J Pallen MGI:2445612 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants exhibit misoriented, even inverted, apical dendrites in layer V pyramidal neurons in the somatosensory and visual cortices and misoriented dendrites in the motor cortex
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the Morris water maze learning, mutants show increased latencies to reach the hidden platform compared to wild-type on acquisition, but no memory deficits on probe trials
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• homozygotes spend about 20% more time in the open areas of the zero-maze indicating decreased anxiety, however they do not show differences in head dips and stretch-attend movements
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• decrease in both horizontal and vertical activity
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• mutants show decreased exploratory locomotor activity, but respond normally to a challenge dose of D-methamphetamine
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| N |
• mutants have normal body weights, circulating levels of glucose and insulin in fed and fasted states, and blood glucose clearance in glucose and insulin tolerance tests, however they show a reduced, or more rapidly attenuated, insulin-stimulated interaction between IRS-1 and PI3-K in the liver
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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