Phenotypes associated with this allele

• Allele Symbol: Pex11a^tm1Sjg
• Allele Name: targeted mutation 1, Stephen J Gould
• Allele ID: MGI:2445440
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pex11a^tm1Sjg/Pex11a^tm1Sjg	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3042886
cx2	Pex11a^tm1Sjg/Pex11a^tm1Sjg Pex11b^tm1Sjg/Pex11b^tm1Sjg	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3042891

Genotype
MGI:3042886

hm1

• Allelic Composition: Pex11a^tm1Sjg/Pex11a^tm1Sjg
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

abnormal hepatocyte mitochondrial morphology ( J:80124 )

• decreased proliferation of mitochondria

• mitochondria with unusual parallel cristae in midzonal and periportal hepatocytes

• many mitochondria with tight associations with lipid droplets

cellular

abnormal hepatocyte mitochondrial morphology ( J:80124 )

• decreased proliferation of mitochondria

• mitochondria with unusual parallel cristae in midzonal and periportal hepatocytes

• many mitochondria with tight associations with lipid droplets

abnormal peroxisome morphology ( J:80124 )

• tendancy for clustering of peroxisomes

Genotype
MGI:3042891

cx2

• Allelic Composition: Pex11a^tm1Sjg/Pex11a^tm1Sjg; Pex11b^tm1Sjg/Pex11b^tm1Sjg
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

perinatal lethality ( J:80124 )

prenatal lethality ( J:80124 )

cellular

abnormal peroxisome morphology ( J:80124 )

• peroxisome number about 1/2 normal, about the same as in Pex11b^tm1Sjg homozygotes

abnormal peroxisome physiology ( J:80124 )

• very mild defects in peroxisomal metabolic functions

• no abnormalities in peroxisomal protein import

growth/size/body

abnormal embryonic growth/weight/body size ( J:80124 )