Phenotypes associated with this allele

• Allele Symbol: Bmpr2^tm1Kml
• Allele Name: targeted mutation 1, Karen M Lyons
• Allele ID: MGI:2445437
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmpr2^tm1Kml/Bmpr2^tm1Kml	either: (involves: 129X1/SvJ * BALB/cJ) or (involves: 129X1/SvJ * C57BL/6J)	MGI:2451321

Genotype
MGI:2451321

hm1

• Allelic Composition: Bmpr2^tm1Kml/Bmpr2^tm1Kml
• Genetic Background: either: (involves: 129X1/SvJ * BALB/cJ) or (involves: 129X1/SvJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:80024 )

• onset of embryonic death occurs between E12 and birth with embryos displaying cardiovascular defects

cardiovascular system

interrupted aortic arch ( J:80024 )

• interruption of the aortic arch

absent vitelline blood vessels ( J:80024 )

• regions of the yolk sac lacked vascularization

abnormal interventricular septum morphology ( J:80024 )

• incomplete ventricular septation

abnormal semilunar valve morphology ( J:80024 )

• absence of semilunar valves

embryo

absent vitelline blood vessels ( J:80024 )

• regions of the yolk sac lacked vascularization

skeleton

decreased rib number ( J:80024 )

• absence of 13th rib pair

delayed bone ossification ( J:80024 )

• affects both endochondral and membranous bones

• most severe in lateral ossification centers of cervical vertebrae C3-C6, fourth sternebra, ventral processes of cervical vertebrae C1-C4, and the interparietal bone