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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(COL2A1-cre)1Wag
transgene insertion 1, Erwin F Wagner
MGI:2445431
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Juntm4Wag/Juntm4Wag
Tg(COL2A1-cre)1Wag/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:2451284
cn2
 		Fosl2tm2Wag/Fosl2tm2Wag
Tg(COL2A1-cre)1Wag/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3522178


Genotype
MGI:2451284
cn1
Allelic
Composition		 Juntm4Wag/Juntm4Wag
Tg(COL2A1-cre)1Wag/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Juntm4Wag mutation (0 available); any Jun mutation (14 available)
Tg(COL2A1-cre)1Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton




Genotype
MGI:3522178
cn2
Allelic
Composition		 Fosl2tm2Wag/Fosl2tm2Wag
Tg(COL2A1-cre)1Wag/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosl2tm2Wag mutation (0 available); any Fosl2 mutation (11 available)
Tg(COL2A1-cre)1Wag mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:94393 )
• died between P10 and P25

growth/size/body
decreased body size ( J:94393 )
decreased body weight ( J:94393 )
postnatal growth retardation ( J:94393 )
• growth retardation after P1

skeleton
decreased width of hypertrophic chondrocyte zone ( J:94393 )
• narrower zone of hypertrophic chondrocytes in P5-P23 femoral growth plates
kyphosis ( J:94393 )
• developed kyphosis between P5 and P10
abnormal chondrocyte morphology ( J:94393 )
• reduced zone of proliferating chondrocytes in femoral growth plates at P23 but not at P5 or P10
decreased bone mineralization ( J:94393 )
• smaller mineralized regions in long bones




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory