Phenotypes associated with this allele

• Allele Symbol: Sgk1^tm1Kuhl
• Allele Name: targeted mutation 1, Dietmar Kuhl
• Allele ID: MGI:2445418
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sgk1^tm1Kuhl/Sgk1^tm1Kuhl	either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * 129X1/SvJ)	MGI:3037197
hm2	Sgk1^tm1Kuhl/Sgk1^tm1Kuhl	involves: 129S1/Sv * 129X1/SvJ	MGI:6446980

Genotype
MGI:3037197

hm1

• Allelic Composition: Sgk1^tm1Kuhl/Sgk1^tm1Kuhl
• Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * 129X1/SvJ)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased susceptibility to weight loss ( J:80115 )

• suffer from weight loss on a low salt diet but not on a normal diet

homeostasis/metabolism

increased circulating aldosterone level ( J:80115 )

renal/urinary system

decreased renal glomerular filtration rate ( J:80115 )

• although the filtration rate was normal under a normal diet, with a low sodium diet, the filtration rate was low in both distal and proximal tubules

abnormal renal sodium ion transport ( J:80115 )

• impaired ability to retain sodium when dietary NaCl is restricted

Genotype
MGI:6446980

hm2

• Allelic Composition: Sgk1^tm1Kuhl/Sgk1^tm1Kuhl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

cardiovascular system

decreased susceptibility to hypertension ( J:291559 )

• reduced sensitivity to hypoxia-induced pulmonary arterial hypertension (PAH)

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:291559 )

• reduced sensitivity to hypoxia-induced pulmonary arterial hypertension (PAH)

• reduced sensitivity to hypoxia-induced right ventricular hypertrophy

• reduced sensitivity to hypoxia-induced pulmonary arterial remodeling

• reduced sensitivity to hypoxia-induced macrophage blood vessel and lung infiltration