Phenotypes associated with this allele

• Allele Symbol: Slc4a1^tm1Ahc
• Allele Name: targeted mutation 1, Athar H Chishti
• Allele ID: MGI:2441657
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc4a1^tm1Ahc/Slc4a1^tm1Ahc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3027980

Genotype
MGI:3027980

hm1

• Allelic Composition: Slc4a1^tm1Ahc/Slc4a1^tm1Ahc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:35637 )

• 80-90% of animals die within two weeks of birth

growth/size/body

decreased body size ( J:35637 )

• noted in animals surviving to adulthood

postnatal growth retardation ( J:35637 )

• growth retardation noted by postnatal day 9

enlarged spleen ( J:35637 )

hematopoietic system

enlarged spleen ( J:35637 )

microcytic anemia ( J:35637 )

abnormal erythrocyte morphology ( J:35637 )

• unusual projections on the surface of red blood cells

decreased erythrocyte cell number ( J:35637 )

decreased hematocrit ( J:35637 )

abnormal hemoglobin ( J:35637 )

decreased hemoglobin content ( J:35637 )

abnormal mean corpuscular volume ( J:35637 )

decreased mean corpuscular volume ( J:35637 )

microcytosis ( J:35637 )

spherocytosis ( J:35637 )

immune system

abnormal immune system organ morphology ( J:35637 )

enlarged spleen ( J:35637 )

integument

pallor ( J:35637 )

• pale appearance noted at birth