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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Egln1+
wild type
MGI:2441283
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Egln1tm2.2Fsl/Egln1+ B6.Cg-Egln1tm2.2Fsl MGI:5525148
ht2
 		Egln1tm1.1Fsl/Egln1+ C57BL/6-Egln1tm1.1Fsl MGI:5521398
ht3
 		Egln1tm1Fong/Egln1+ involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:3690224
cn4
 		Egln1tm2.1Fsl/Egln1+
Pax3tm1(cre)Joe/Pax3+ 		involves: 129 * C57BL/6 MGI:5525141
cx5
 		Egln1tm1.1Fsl/Egln1+
Hif1atm3.1Rsjo/Hif1a+ 		B6.Cg-Egln1tm1.1Fsl Hif1atm3.1Rsjo MGI:5525151


Genotype
MGI:5525148
ht1
Allelic
Composition		 Egln1tm2.2Fsl/Egln1+
Genetic
Background		 B6.Cg-Egln1tm2.2Fsl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm2.2Fsl mutation (0 available); any Egln1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased spleen weight ( J:202737 )
• spleen weight is slightly increased as compared to wild-type
polycythemia ( J:202737 )
• mice exhibit erythrocytosis, however, erythropoietin levels are not increased

immune system
increased spleen weight ( J:202737 )
• spleen weight is slightly increased as compared to wild-type

respiratory system

growth/size/body
increased spleen weight ( J:202737 )
• spleen weight is slightly increased as compared to wild-type




Genotype
MGI:5521398
ht2
Allelic
Composition		 Egln1tm1.1Fsl/Egln1+
Genetic
Background		 C57BL/6-Egln1tm1.1Fsl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm1.1Fsl mutation (1 available); any Egln1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased spleen weight ( J:202737 )
• spleen weight is increased as compared to wild-type
polycythemia ( J:202737 )
• mice exhibit erythrocytosis, however, erythropoietin levels are not increased

immune system
increased spleen weight ( J:202737 )
• spleen weight is increased as compared to wild-type

respiratory system
increased tidal volume ( J:202737 )
• under normoxia conditions
increased pulmonary ventilation ( J:202737 )
• under normoxia conditions

growth/size/body
increased spleen weight ( J:202737 )
• spleen weight is increased as compared to wild-type




Genotype
MGI:3690224
ht3
Allelic
Composition		 Egln1tm1Fong/Egln1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm1Fong mutation (0 available); any Egln1 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
muscle phenotype ( J:132630 )
N
• after 7 days of ischemia induced by femoral artery ligation, mice display extensive muscle necrosis, similar in extent to wild-type animals




Genotype
MGI:5525141
cn4
Allelic
Composition		 Egln1tm2.1Fsl/Egln1+
Pax3tm1(cre)Joe/Pax3+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm2.1Fsl mutation (0 available); any Egln1 mutation (23 available)
Pax3tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
polycythemia ( J:202737 )
• mice exhibit erythrocytosis, however, erythropoietin levels are not increased
increased hematocrit ( J:202737 )
• hematocrits are modestly (60%) increased over controls




Genotype
MGI:5525151
cx5
Allelic
Composition		 Egln1tm1.1Fsl/Egln1+
Hif1atm3.1Rsjo/Hif1a+
Genetic
Background		 B6.Cg-Egln1tm1.1Fsl Hif1atm3.1Rsjo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln1tm1.1Fsl mutation (1 available); any Egln1 mutation (23 available)
Hif1atm3.1Rsjo mutation (0 available); any Hif1a mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory