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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Polh+
wild type
MGI:2441177
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Polhtm2Fmh/Polh+ B6.129-Polhtm2Fmh MGI:3691208
ht2
 		Polhtm1.1Rak/Polh+ involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:3615446


Genotype
MGI:3691208
ht1
Allelic
Composition		 Polhtm2Fmh/Polh+
Genetic
Background		 B6.129-Polhtm2Fmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm2Fmh mutation (0 available); any Polh mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by UV-induction ( J:115000 )
• epithelial tumors developed in 5 of 9 mice during a 10 week resting period after 20 weeks of UV-B exposure compared to 0 o8 wild-type mice

homeostasis/metabolism
increased incidence of tumors by UV-induction ( J:115000 )
• epithelial tumors developed in 5 of 9 mice during a 10 week resting period after 20 weeks of UV-B exposure compared to 0 o8 wild-type mice




Genotype
MGI:3615446
ht2
Allelic
Composition		 Polhtm1.1Rak/Polh+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polhtm1.1Rak mutation (0 available); any Polh mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by UV-induction ( J:105034 )
• increased incidence several months after UV-irradiation
increased skin tumor incidence ( J:105034 )
• increased susceptibility over wild-type to develop skin tumors

integument
increased skin tumor incidence ( J:105034 )
• increased susceptibility over wild-type to develop skin tumors

homeostasis/metabolism
increased incidence of tumors by UV-induction ( J:105034 )
• increased incidence several months after UV-irradiation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory