All Phenotypes Sun1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sun1⁺
wild type
MGI:2441046

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Sun1^tm1Mhan/Sun1⁺ Sun2^tm1Mhan/Sun2^tm1Mhan	involves: 129S6/SvEvTac	MGI:3850094
cx2	Sun1^tm1.1Ktj/Sun1⁺ Sun2^tm1.1Cyh/Sun2^tm1.1Cyh	involves: 129/Sv * C57BL/6 * C57BL/6N	MGI:5824548

Allelic Composition	Sun1^tm1Mhan/Sun1⁺ Sun2^tm1Mhan/Sun2^tm1Mhan
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun1^tm1Mhan mutation (1 available); any Sun1 mutation (63 available)
Sun2^tm1Mhan mutation (1 available); any Sun2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle morphology ( J:150047 )

• 49% of muscle cells have no nuclei beneath neuromuscular junctions unlike in wild-type mice

Allelic Composition	Sun1^tm1.1Ktj/Sun1⁺ Sun2^tm1.1Cyh/Sun2^tm1.1Cyh
Genetic Background	involves: 129/Sv * C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun1^tm1.1Ktj mutation (0 available); any Sun1 mutation (63 available)
Sun2^tm1.1Cyh mutation (0 available); any Sun2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:224769 )

N	• at P30, mice show grossly normal cerebellar size relative to wild-type controls

abnormal Purkinje cell morphology ( J:224769 )

• at P14, 32% of Syne2 is localized at the nuclear membrane of Purkinje cells relative to 44% in wild-type cells

growth/size/body

growth/size/body region phenotype ( J:224769 )

N	• at 3-4 months of age, average body weight is similar to that of wild-type controls

behavior/neurological

behavior/neurological phenotype ( J:224769 )

N	• adult mice exhibit normal motor coordination, as assessed by rotarod performance and footprint analysis

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