Phenotypes associated with this allele

• Allele Symbol: Lonp1⁺
• Allele Name: wild type
• Allele ID: MGI:2440942
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Lonp1^tm1b(EUCOMM)Hmgu/Lonp1^+	C57BL/6N-Lonp1^tm1b(EUCOMM)Hmgu/Ieg	MGI:5797635
ht2	Lonp1^tm1Otin/Lonp1^+	Not Specified	MGI:5707193

Genotype
MGI:5797635

ht1

• Allelic Composition: Lonp1^{tm1b(EUCOMM)Hmgu}/Lonp1⁺
• Genetic Background: C57BL/6N-Lonp1^{tm1b(EUCOMM)Hmgu}/Ieg
• Cell Lines: HEPD0936_3_B11

Data Sources

IMPC Data for Lonp1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased lean body mass ( J:211773 )

♀

IMPC - HMGU

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:211773 )

♀

IMPC - HMGU

decreased circulating iron level ( J:211773 )

IMPC - HMGU

nervous system

decreased prepulse inhibition ( J:211773 )

IMPC - HMGU

skeleton

abnormal bone structure ( J:211773 )

♀

IMPC - HMGU

increased bone mineral content ( J:211773 )

♀

IMPC - HMGU

vision/eye

abnormal lens morphology ( J:211773 )

♀

IMPC - HMGU

Genotype
MGI:5707193

ht2

• Allelic Composition: Lonp1^tm1Otin/Lonp1⁺
• Genetic Background: Not Specified

neoplasm

decreased incidence of tumors by chemical induction ( J:221992 )

• mice treated with azoxymethane (AOM) and dextrane sulfate exhibit fewer incidences and numbers of colorectal tumors compared with wild-type mice

• mice treated with a 7,12-dimethylbenzanthracene and tetradecanoylphorbol acetate (DMBA/TPA) develop fewer and smaller papillomas compared with wild-type mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:221992 )

• mice treated with azoxymethane (AOM) and dextrane sulfate exhibit fewer incidences and numbers of colorectal tumors compared with wild-type mice

• mice treated with a 7,12-dimethylbenzanthracene and tetradecanoylphorbol acetate (DMBA/TPA) develop fewer and smaller papillomas compared with wild-type mice