Phenotypes associated with this allele

• Allele Symbol: Cntnap4⁺
• Allele Name: wild type
• Allele ID: MGI:2440921
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cntnap4^tm1Pele/Cntnap4^+	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:5585149

Genotype
MGI:5585149

ht1

• Allelic Composition: Cntnap4^tm1Pele/Cntnap4⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased grooming behavior ( J:211338 )

• high penetrance of over-grooming that results in whisker, face, and sometimes body hair loss but rarely lesions

• excessive grooming is apparent before weaning

increased startle reflex ( J:211338 )

• elevation of startle responses and abnormal prepulse inhibition (PPI) indexes

• mice treated with indiplon, a specific positive allosteric modulator for GABA(A) receptors, show restoration of the startle response

nervous system

abnormal synapse morphology ( J:211338 )

• inhibitory synapses exhibit a widening of the synaptic cleft and a shorter inhibitory postsynaptic density

abnormal postsynaptic density morphology ( J:211338 )

• inhibitory synapses exhibit a widening of the synaptic cleft and a shorter inhibitory postsynaptic density

abnormal prepulse inhibition ( J:211338 )

• abnormal PPI indexes

homeostasis/metabolism

increased dopamine level ( J:211338 )

• mice show an increase in peak extracellular dopamine concentration, especially with multiple pulse stimulation, that is more pronounced in the nucleus accumbens than in the caudate putamen

• evoked peak extracellular dopamine concentration is enhanced evenly across frequencies varying from 5 to 100 Hz

• maximum dopamine uptake rates are somewhat higher in mutants, however excitability of dopaminergic neurons is unaffected