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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mcoln3+
wild type
MGI:2440801
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Mcoln3Va-J/Mcoln3+ B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J MGI:4429715
ht2
 		Mcoln3Va/Mcoln3+ involves: C57BL * C57BR MGI:3696789
ht3
 		Mcoln3Va/Mcoln3+ mixed MGI:3696960
ht4
 		Mcoln3Va-J/Mcoln3+ Not Specified MGI:3697408


Genotype
MGI:4429715
ht1
Allelic
Composition		 Mcoln3Va-J/Mcoln3+
Genetic
Background		 B6C3Fe-a/a Hoxa13Hd Mcoln3Va-J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcoln3Va-J mutation (4 available); any Mcoln3 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
diluted coat color ( J:78812 )
• heterozygotes express a slightly diluted coat color which is less diluted than that of the original veritant waddler heterozygotes
belly spot ( J:78812 )
• heterozygotes express a small white ventral spot
head spot ( J:78812 )
• some heterozygotes have a white forehead patch

hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:78812 )
• at 2 weeks of age heterozygotes respond to 8- and 16-kHz stimuli only at sound pressure levels of 88 dB and 94 dB respectively, no response was found to click or 32 kHz stimuli, and at 3 weeks of age thresholds increased to >100 dB, which, although it is an early and rapidly progressing hearing loss, is a less severe phenotype than in mice heterozygous for the original veritant waddler mutation

integument
diluted coat color ( J:78812 )
• heterozygotes express a slightly diluted coat color which is less diluted than that of the original veritant waddler heterozygotes
belly spot ( J:78812 )
• heterozygotes express a small white ventral spot
head spot ( J:78812 )
• some heterozygotes have a white forehead patch




Genotype
MGI:3696789
ht2
Allelic
Composition		 Mcoln3Va/Mcoln3+
Genetic
Background		 involves: C57BL * C57BR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcoln3Va mutation (2 available); any Mcoln3 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:78812 )
• at 2 weeks of age heterozygotes only return positive waveforms to an 8 kHz stimulus at 95 dB and by 3 weeks of age there is no response to click or 32 kHz stimuli

behavior/neurological
jumpy ( J:13133 )
• in reaction to sudden jarring
head tossing ( J:13133 )
• choreic head movements
abnormal locomotor coordination ( J:13133 )
• waddling "duck like" walk
hyperactivity ( J:13133 )
• usually in motion when not asleep, nodding and tossing their heads
circling ( J:13133 )
• mixed circling habits are present as early as 14 days after birth
abnormal maternal nurturing ( J:13133 )
• neglect their young and trample pups
tonic seizures ( J:13133 )
• a convulsive stiffening of the body in reaction ot sudden jarring

nervous system
tonic seizures ( J:13133 )
• a convulsive stiffening of the body in reaction ot sudden jarring

pigmentation
variegated coat color ( J:13133 )
• with patches of normal-colored, diluted, and white fur
mottled coat ( J:78812 )
• coat color is more dilute and mottled than in Va-J heterozygotes, with an entirely white ventrum and a large white spot on the forehead

reproductive system
reduced fertility ( J:13133 )
• some of the heterozygous mice, especially the males are sterile

integument
variegated coat color ( J:13133 )
• with patches of normal-colored, diluted, and white fur
mottled coat ( J:78812 )
• coat color is more dilute and mottled than in Va-J heterozygotes, with an entirely white ventrum and a large white spot on the forehead




Genotype
MGI:3696960
ht3
Allelic
Composition		 Mcoln3Va/Mcoln3+
Genetic
Background		 mixed
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcoln3Va mutation (2 available); any Mcoln3 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired coordination ( J:13046 )
• a marked inability to negotiate a narrow bridge at two or three days before their eyes open
impaired swimming ( J:13046 )
• elderly heterozygous mice over 10 months old cannot swim

hearing/vestibular/ear
abnormal cochlear hair cell morphology ( J:13046 )
• unequal size of the hair cells by 11 day
cochlear hair cell degeneration ( J:13046 )
• some of hair cells disappear entirely by the 17th day
• the others are drastically reduced
abnormal stria vascularis morphology ( J:13046 )
• becomes distinctly abnormal at the age of 17 days
• nuclei becomes rounded and later lose their cytoplasmic processes
detached tectorial membrane ( J:13046 )
• loses all contact with the organ of Corti by 7 days
• remain detached from the organ of Corti and later shrivels up
enlarged tectorial membrane ( J:13046 )
• staring 4 days of age
• the tectorial membrane in mutant mice forms a big bulge instead of forming a thin strand of the outer marginal zone
abnormal crista ampullaris morphology ( J:13046 )
• at age of 25 days the hairs have mostly disappeared
• the gelatinous cupula remains

nervous system
abnormal cochlear hair cell morphology ( J:13046 )
• unequal size of the hair cells by 11 day
cochlear hair cell degeneration ( J:13046 )
• some of hair cells disappear entirely by the 17th day
• the others are drastically reduced
abnormal vestibulocochlear ganglion morphology ( J:13046 )
• a change in the shape of the cells and their nuclei are seen starting at the age of 6 days
cochlear ganglion degeneration ( J:13046 )
• a reduction in cell size and density by 9 days
• destruction of nerve cells through life
abnormal vestibular ganglion morphology ( J:13046 )
• the average cell size in the vestibular ganglion is reduced




Genotype
MGI:3697408
ht4
Allelic
Composition		 Mcoln3Va-J/Mcoln3+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcoln3Va-J mutation (4 available); any Mcoln3 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear

behavior/neurological
behavior/neurological phenotype ( J:64107 )
N
• behave normally unlike Mcoln3Va

pigmentation
variegated coat color ( J:64107 )
• a slightly dilute coat color, large irregular belly spots and white feet and tail tips
• not as varicolored as unlike Mcoln3Va
belly spot ( J:5286 )
• mice exhibit a large, irregular belly spot

limbs/digits/tail

integument
variegated coat color ( J:64107 )
• a slightly dilute coat color, large irregular belly spots and white feet and tail tips
• not as varicolored as unlike Mcoln3Va
belly spot ( J:5286 )
• mice exhibit a large, irregular belly spot




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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory