Phenotypes associated with this allele

• Allele Symbol: Mmrn1⁺
• Allele Name: wild type
• Allele ID: MGI:2440641
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mmrn1^tm1d(EUCOMM)Hmgu/Mmrn1^+	B6(Cg)-Mmrn1^tm1d(EUCOMM)Hmgu	MGI:7852429

Genotype
MGI:7852429

ht1

• Allelic Composition: Mmrn1^{tm1d(EUCOMM)Hmgu}/Mmrn1⁺
• Genetic Background: B6(Cg)-Mmrn1^{tm1d(EUCOMM)Hmgu}
• Cell Lines: HEPD0617_6_G03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:307643 )

N • mice show no overt bleeding and have normal plasma and platelet von Willebrand factor levels and normal bleeding time and wound blood loss after tail transection (up to 900 s) relative to wild-type controls

abnormal platelet physiology ( J:307643 )

• in high shear flow assays using whole blood, platelets show decreased adhesion to Horm collagen and fail to form the large adherent aggregates observed with wild-type platelets

decreased susceptibility to induced thrombosis ( J:307643 )

• in the FeCl₃-induced mesenteric vessel injury model, mice have a significantly lower number of platelets localized to the vessel wall 3-5 min post-injury and show delayed appearance of the first large thrombus (greater or equal to 20 um)

• 3 of 7 mice fail to form a large thrombus; when large thrombi are formed, small platelet aggregates dissociate rapidly

• all (7 of 7) mice fail to form an occlusive thrombus by 40 min, whereas all (11 of 11) wild-type controls form an occlusive thrombus by 10 to 35 min after injury

hematopoietic system

hematopoietic system phenotype ( J:307643 )

N • mice show normal platelet, erythrocyte and leukocyte counts relative to wild-type controls

abnormal platelet physiology ( J:307643 )

• in high shear flow assays using whole blood, platelets show decreased adhesion to Horm collagen and fail to form the large adherent aggregates observed with wild-type platelets