All Phenotypes Rab3b<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rab3b⁺
wild type
MGI:2440609

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b⁺ Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja	involves: 129 * 129P2/OlaHsd	MGI:3625948

Allelic Composition	Rab3a^tm1Sud/Rab3a^tm1Sud Rab3b^tm1Sud/Rab3b⁺ Rab3c^tm1Sud/Rab3c^tm1Sud Rab3d^tm1Rja/Rab3d^tm1Rja
Genetic Background	involves: 129 * 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab3a^tm1Sud mutation (2 available); any Rab3a mutation (17 available)
Rab3b^tm1Sud mutation (1 available); any Rab3b mutation (12 available)
Rab3c^tm1Sud mutation (1 available); any Rab3c mutation (19 available)
Rab3d^tm1Rja mutation (1 available); any Rab3d mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:105478 )

• 50% of triple Rab3 knockouts with one copy of Rab3c survive

growth/size/body

decreased body weight ( J:105478 )

• male and female triple knockouts which are deficient for Rab3a and heterozygous for Rab3b display a weight decrease at 5 weeks of age

respiratory system

respiratory distress ( J:105478 )

• triple knockouts lacking Rab3a show respiratory impairment similar to, but less severe than that shown by quadruple knockouts

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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