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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sumo2+
wild type
MGI:2440606
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Sumo2tm1Weiy/Sumo2+ involves: 129 * C57BL/6 MGI:5641948
cx2
 		Sumo2tm1Weiy/Sumo2+
Sumo3tm1Weiy/Sumo3+ 		involves: 129 * C57BL/6 MGI:5690071
cx3
 		Sumo2tm1Weiy/Sumo2+
Sumo3tm1Weiy/Sumo3tm1Weiy 		involves: 129 * C57BL/6 MGI:5690075


Genotype
MGI:5641948
ht1
Allelic
Composition		 Sumo2tm1Weiy/Sumo2+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sumo2tm1Weiy mutation (1 available); any Sumo2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:217019 )
• heterozygotes are viable and fertile and exhibit no gross abnormalities in size or weight relative to wild-type littermate controls




Genotype
MGI:5690071
cx2
Allelic
Composition		 Sumo2tm1Weiy/Sumo2+
Sumo3tm1Weiy/Sumo3+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sumo2tm1Weiy mutation (1 available); any Sumo2 mutation (15 available)
Sumo3tm1Weiy mutation (1 available); any Sumo3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:217019 )
• double heterozygotes are viable and display no overt phenotype




Genotype
MGI:5690075
cx3
Allelic
Composition		 Sumo2tm1Weiy/Sumo2+
Sumo3tm1Weiy/Sumo3tm1Weiy
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sumo2tm1Weiy mutation (1 available); any Sumo2 mutation (15 available)
Sumo3tm1Weiy mutation (1 available); any Sumo3 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:217019 )
• only 2 mutant mice are found at birth in 35 litters after crossing mice that are double heterozygous for Sumo2tm1Weiy and Sumo3tm1Weiy with Sumo3tm1Weiy homozygotes

growth/size/body
decreased birth body size ( J:217019 )
• although mutant mice show no overt phenotype at E15.5 and E17.5, they are considerably smaller than Sumo3tm1Weiy homozygotes at birth (E19.5)
decreased body size ( J:217019 )
• at P10, mutant mice are significantly smaller than Sumo3tm1Weiy homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory