Phenotypes associated with this allele

• Allele Symbol: Mllt3⁺
• Allele Name: wild type
• Allele ID: MGI:2440580
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mllt3^tm1b(EUCOMM)Hmgu/Mllt3^+	C57BL/6N-Mllt3^tm1b(EUCOMM)Hmgu/Cnrm	MGI:5757365
cn2	Kmt2a^tm1Thr/Kmt2a^+ Mllt3^tm2Thr/Mllt3^+ Tg(Lck-cre)1Thr/?	involves: 129S/SvEv	MGI:3720075

Genotype
MGI:5757365

ht1

• Allelic Composition: Mllt3^{tm1b(EUCOMM)Hmgu}/Mllt3⁺
• Genetic Background: C57BL/6N-Mllt3^{tm1b(EUCOMM)Hmgu}/Cnrm
• Cell Lines: HEPD0538_4_B06

Data Sources

IMPC Data for Mllt3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

♀

IMPC - HAR

behavior/neurological

hyperactivity ( J:211773 )

IMPC - HAR

hematopoietic system

thrombocytopenia ( J:211773 )

IMPC - HAR

homeostasis/metabolism

increased circulating amylase level ( J:211773 )

♂

IMPC - HAR

renal/urinary system

decreased kidney weight ( J:211773 )

♂

IMPC - HAR

skeleton

abnormal clavicle morphology ( J:211773 )

IMPC - HAR

vision/eye

cataract ( J:211773 )

IMPC - HAR

Genotype
MGI:3720075

cn2

• Allelic Composition: Kmt2a^tm1Thr/Kmt2a⁺; Mllt3^tm2Thr/Mllt3⁺; Tg(Lck-cre)1Thr/?
• Genetic Background: involves: 129S/SvEv

neoplasm

increased hemolymphoid system tumor incidence ( J:100794 )

• 18 of 20 mice develop hematopoeitic neoplasm that are either T cell or myeloid in origin

• infiltration of malignant cells occurs in the liver, kidney, lungs and lymph nodes

increased T cell derived lymphoma incidence ( J:100794 )

• mice develop small T cell lymphomas

increased leukemia incidence ( J:100794 )

• mice have myelo-proliferative-like myeloid leukemia without circulating leukemic cells

hematopoietic system

increased T cell derived lymphoma incidence ( J:100794 )

• mice develop small T cell lymphomas

enlarged spleen ( J:100794 )

• splenomeglia is caused by a repopulation of the spleen with malignant cells

abnormal spleen red pulp morphology ( J:100794 )

• red and white pulp architecture is lost

abnormal spleen white pulp morphology ( J:100794 )

• red and white pulp architecture is lost

immune system

increased T cell derived lymphoma incidence ( J:100794 )

• mice develop small T cell lymphomas

enlarged spleen ( J:100794 )

• splenomeglia is caused by a repopulation of the spleen with malignant cells

abnormal spleen red pulp morphology ( J:100794 )

• red and white pulp architecture is lost

abnormal spleen white pulp morphology ( J:100794 )

• red and white pulp architecture is lost

growth/size/body

enlarged spleen ( J:100794 )

• splenomeglia is caused by a repopulation of the spleen with malignant cells

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:100794 )

• mice develop small T cell lymphomas