All Phenotypes Rock2<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rock2^tm1Zpj/Rock2⁺	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:5692192
ht2	Rock2^tm1.1Liao/Rock2⁺	involves: C57BL/6	MGI:3795924
cn3	Rock2^tm1.1Itl/Rock2⁺ Tg(Tagln-cre)1Her/0	B6.Cg-Rock2^tm1.1Itl Tg(Tagln-cre)1Her	MGI:5702757
cx4	Fhl2^tm1Chen/Fhl2⁺ Rock2^tm1.1Liao/Rock2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5491823

Allelic Composition	Rock2^tm1Zpj/Rock2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock2^tm1Zpj mutation (0 available); any Rock2 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:224630 )

N	• mice fed normal chow or a high-fat diet exhibit normal fasting blood glucose levels and cardiac triglyceride levels

decreased susceptibility to diet-induced obesity ( J:224630 )

• mice fed a high-fat diet exhibit slightly less weight gain compared with wild-type mice

abnormal circulating cholesterol level ( J:224630 )

• mice fed a high-fat diet do not exhibit an increase in serum cholesterol unlike wild-type mice

decreased circulating free fatty acids level ( J:224630 )

• lower in mice fed a high-fat diet compared with mice fed standard chow

improved glucose tolerance ( J:224630 )

• mice fed a high-fat diet exhibit improved insulin tolerance compared with wild-type mice

cardiovascular system

abnormal cardiovascular system morphology ( J:224630 )

• mice fed a high-fat diet exhibit normal heart weight, left ventricular mass and left ventricular end-diastolic internal diameter unlike wild-type mice

abnormal cardiovascular system physiology ( J:224630 )

• mice fed a high-fat diet do not exhibit a change in cardiac function unlike wild-type mice

growth/size/body

growth/size/body region phenotype ( J:224630 )

N	• mice fed normal chow exhibit normal body weight

decreased susceptibility to diet-induced obesity ( J:224630 )

• mice fed a high-fat diet exhibit slightly less weight gain compared with wild-type mice

Allelic Composition	Rock2^tm1.1Liao/Rock2⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock2^tm1.1Liao mutation (0 available); any Rock2 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:135152 )

N	• mice exhibit normal blood vessel healing

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to hypertension ( J:222206 )

• hypoxia-induced pulmonary hypertension is ameliorated in mutants

• hypoxia-induced increases in right ventricular systolic pressure, right ventricular end-diastolic pressure, peak rates of right ventricular pressure development and relaxation, right ventricle hypertrophy, pulmonary vascular remodeling, the number of CD45+ inflammatory cells in the hypoxic pulmonary artery, and pulmonary vascular cell proliferation are suppressed in mutants compared to controls

• however, mice show no differences in heart rate, systemic blood pressure, or left ventricular hemodynamic parameters before or after chronic hypoxia, no differences in pulmonary vasculature and right ventricular systolic pressure under normoxic conditions, and no differences in hemoglobin levels and platelet counts following long-term exposure to hypoxia compared to controls

abnormal vascular smooth muscle physiology ( J:222206 )

• in vitro, aortic vascular smooth muscle migration in response to fetal bovine serum is decreased

decreased vascular smooth muscle cell proliferation ( J:222206 )

• in vitro, aortic vascular smooth muscle cell proliferation in response to fetal bovine serum is decreased

immune system

abnormal cytokine secretion ( J:222206 )

• levels of inflammatory cytokines like interferon-gamma and TNF-alpha secreted by vascular smooth muscle cells are reduced under both normoxic and hypoxic conditions

muscle

abnormal vascular smooth muscle physiology ( J:222206 )

• in vitro, aortic vascular smooth muscle migration in response to fetal bovine serum is decreased

decreased vascular smooth muscle cell proliferation ( J:222206 )

• in vitro, aortic vascular smooth muscle cell proliferation in response to fetal bovine serum is decreased

cellular

decreased vascular smooth muscle cell proliferation ( J:222206 )

• in vitro, aortic vascular smooth muscle cell proliferation in response to fetal bovine serum is decreased

Allelic Composition	Fhl2^tm1Chen/Fhl2⁺ Rock2^tm1.1Liao/Rock2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fhl2^tm1Chen mutation (0 available); any Fhl2 mutation (18 available)
Rock2^tm1.1Liao mutation (0 available); any Rock2 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:196433 )

N	• hypertrophic and fibrosis responses to Ang II are similar to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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