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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cthrc1+
wild type
MGI:2440496
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cthrc1tm1Hssk/Cthrc1+
Vangl2Lp/Vangl2+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3815075
cx2
 		Cthrc1tm1Hssk/Cthrc1+
Vangl2Lp/Vangl2+ 		involves: 129P2/OlaHsd * C57BL/6 * CD-1 MGI:3815079


Genotype
MGI:3815075
cx1
Allelic
Composition		 Cthrc1tm1Hssk/Cthrc1+
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cthrc1tm1Hssk mutation (1 available); any Cthrc1 mutation (34 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neural tube closure ( J:140886 )
• Background Sensitivity: defects seen in the midbrain region at E13.5

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:140886 )
N
• sensory hair cells in the cochlea are normal

embryo
abnormal neural tube closure ( J:140886 )
• Background Sensitivity: defects seen in the midbrain region at E13.5




Genotype
MGI:3815079
cx2
Allelic
Composition		 Cthrc1tm1Hssk/Cthrc1+
Vangl2Lp/Vangl2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cthrc1tm1Hssk mutation (1 available); any Cthrc1 mutation (34 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:140886 )
N
• Background Sensitivity: no defects in neural tube closure are seen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory