Phenotypes associated with this allele

• Allele Symbol: Kat8⁺
• Allele Name: wild type
• Allele ID: MGI:2440426
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Kat8^em1(IMPC)Mbp/Kat8^+	C57BL/6N-Kat8^em1(IMPC)Mbp/MbpMmucd	MGI:6461361
cn2	Gt(ROSA)26Sor^tm1(cre/ERT2)Thl/Gt(ROSA)26Sor^+ Kat8^tm1Thl/Kat8^+	involves: 129S1/Sv	MGI:3769383
cx3	Atm^tm1Led/Atm^+ Kat8^tm2Thl/Kat8^+	involves: 129S1/Sv * 129S6/SvEvTac	MGI:3769385
cx4	Atm^tm1Led/Atm^tm1Led Kat8^tm2Thl/Kat8^+	involves: 129S1/Sv * 129S6/SvEvTac	MGI:3769386
cx5	Kat8^tm2Thl/Kat8^+ Trp53^tm1Brd/Trp53^tm1Brd	involves: 129S1/Sv * 129S7/SvEvBrd	MGI:3769387

Genotype
MGI:6461361

ht1

• Allelic Composition: Kat8^em1(IMPC)Mbp/Kat8⁺
• Genetic Background: C57BL/6N-Kat8^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Kat8

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:211773 )

♂

IMPC - UCD

decreased thigmotaxis ( J:211773 )

♂

IMPC - UCD

decreased locomotor activity ( J:211773 )

♂

IMPC - UCD

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

♂

IMPC - UCD

immune system

abnormal lymph node morphology ( J:211773 )

♂

IMPC - UCD

enlarged lymph nodes ( J:211773 )

♂

IMPC - UCD

liver/biliary system

abnormal liver morphology ( J:211773 )

♂

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

♂

IMPC - UCD

small kidney ( J:211773 )

♀

IMPC - UCD

vision/eye

cataract ( J:211773 )

♀

IMPC - UCD

abnormal vitreous body morphology ( J:211773 )

♀

IMPC - UCD

Genotype
MGI:3769383

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺; Kat8^tm1Thl/Kat8⁺
• Genetic Background: involves: 129S1/Sv

cellular

increased cellular sensitivity to ionizing radiation induced cell death ( J:128936 )

• following treatment with tamoxifen, cell survival of mouse embryonic fibroblasts following treatment with ionizing radiation is slightly decreased compared to in wild-type cells

decreased fibroblast proliferation ( J:128936 )

• following treatment with tamoxifen, mouse embryonic fibroblasts exhibit a modest decrease in proliferation compared to wild-type

abnormal DNA repair ( J:128936 )

• following treatment with tamoxifen, the number of chromosome abnormalities in mouse embryonic fibroblasts is increased compared to in wild-type cells

homeostasis/metabolism

increased cellular sensitivity to ionizing radiation induced cell death ( J:128936 )

• following treatment with tamoxifen, cell survival of mouse embryonic fibroblasts following treatment with ionizing radiation is slightly decreased compared to in wild-type cells

abnormal DNA repair ( J:128936 )

• following treatment with tamoxifen, the number of chromosome abnormalities in mouse embryonic fibroblasts is increased compared to in wild-type cells

Genotype
MGI:3769385

cx3

• Allelic Composition: Atm^tm1Led/Atm⁺; Kat8^tm2Thl/Kat8⁺
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

mortality/aging

premature death ( J:128936 )

• only 76% of mice survive the first year

Genotype
MGI:3769386

cx4

• Allelic Composition: Atm^tm1Led/Atm^tm1Led; Kat8^tm2Thl/Kat8⁺
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

mortality/aging

premature death ( J:128936 )

• mice die earlier than Atm^tm1Led homozygotes

growth/size/body

decreased body weight ( J:128936 )

• mice exhibit a modest reduction in weight compared to Atm^tm1Led homozygotes

Genotype
MGI:3769387

cx5

• Allelic Composition: Kat8^tm2Thl/Kat8⁺; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

mortality/aging

premature death ( J:128936 )

• mice die earlier than Trp53^tm1Brdhomozygotes