All Phenotypes Vegfc<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Vegfc⁺
wild type
MGI:2440332

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Vegfc^tm1Ali/Vegfc⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3805198
ht2	Vegfc^tm1Ali/Vegfc⁺	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:3026664
cx3	Tg(KRT14-Vegfd)1Ali/0 Vegfc^tm1Ali/Vegfc⁺	involves: 129S1/Sv * 129X1/SvJ * FVB	MGI:3805325
cx4	Vegfc^tm1Ali/Vegfc⁺ Tg(KRT14-FIGF)2Ali/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3805314

Allelic Composition	Vegfc^tm1Ali/Vegfc⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vegfc^tm1Ali mutation (1 available); any Vegfc mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

lymphatic vessel hypoplasia ( J:137909 )

• hypoplastic lymphatic system in the skin

Allelic Composition	Vegfc^tm1Ali/Vegfc⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vegfc^tm1Ali mutation (1 available); any Vegfc mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

lymphedema ( J:87394 )

• accumlulation of chylous, milky fluid high in triglycerides in the abdomen

• adults show swelling of the paws

chylous ascites ( J:87394 )

• the stagnant chylous ascites produces an inflammatory response in the abdominal cavity and leads to severe adhesions and fibrosis of the internal organs

immune system

abnormal lymph circulation ( J:87394 )

• cutaneous lymphatic vessels do not uptake dextran as seen in wild-type vessels

• no lymphatic fluid transport of Evans blue dye is observed into the collecting lymphatic vessles after intradermal injection of dye to the hind limbs

lymphatic vessel hypoplasia ( J:87394 )

• severe but transient hypoplasia of the lymphatic vasculature in newborns

cardiovascular system

abnormal lymph circulation ( J:87394 )

• cutaneous lymphatic vessels do not uptake dextran as seen in wild-type vessels

• no lymphatic fluid transport of Evans blue dye is observed into the collecting lymphatic vessles after intradermal injection of dye to the hind limbs

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary lymphedema		DOID:0050580	OMIM:PS153100	J:209628

Allelic Composition	Tg(KRT14-Vegfd)1Ali/0 Vegfc^tm1Ali/Vegfc⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-Vegfd)1Ali mutation (1 available)
Vegfc^tm1Ali mutation (1 available); any Vegfc mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal lymphatic vessel morphology ( J:137909 )

• partial rescue of cutaneous lymphatic vascular hypoplasia

• rescue is not as strong as in mice carrying Tg(KRT14-FIGF)2Ali

Allelic Composition	Vegfc^tm1Ali/Vegfc⁺ Tg(KRT14-FIGF)2Ali/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-FIGF)2Ali mutation (0 available)
Vegfc^tm1Ali mutation (1 available); any Vegfc mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

lymphatic vessel hyperplasia ( J:137909 )

• hyperplastic cutaneous lymphatic vasculature

• hyperplasia is not as strong as in transgenic mice wild-type for Vegfc

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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