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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Blnk+
wild type
MGI:2440126
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Blnktm1Achn/Blnk+ involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6 MGI:3836564
cx2
 		Blnktm1Achn/Blnk+
Btktm1Wk/Btktm1Wk
Tg(IGH-Btk)1Witt/0 		involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6 MGI:3836561


Genotype
MGI:3836564
ht1
Allelic
Composition		 Blnktm1Achn/Blnk+
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Achn mutation (1 available); any Blnk mutation (77 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell proliferation ( J:82430 )
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

hematopoietic system
decreased B cell proliferation ( J:82430 )
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

cellular
decreased B cell proliferation ( J:82430 )
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased




Genotype
MGI:3836561
cx2
Allelic
Composition		 Blnktm1Achn/Blnk+
Btktm1Wk/Btktm1Wk
Tg(IGH-Btk)1Witt/0
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Blnktm1Achn mutation (1 available); any Blnk mutation (77 available)
Btktm1Wk mutation (1 available); any Btk mutation (22 available)
Tg(IGH-Btk)1Witt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:82430 )
• impairment in the early and late phases of Ca2+ mobilization following BCR stimulation
decreased B cell proliferation ( J:82430 )
• fail to proliferate after BCR cross linking
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

hematopoietic system
abnormal B cell physiology ( J:82430 )
• impairment in the early and late phases of Ca2+ mobilization following BCR stimulation
decreased B cell proliferation ( J:82430 )
• fail to proliferate after BCR cross linking
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased

cellular
decreased B cell proliferation ( J:82430 )
• fail to proliferate after BCR cross linking
• following cross linking the frequency of cycling cells is reduced and the percentage of cells with greater than 2N DNA is increased




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory