Phenotypes associated with this allele

• Allele Symbol: Rpa1⁺
• Allele Name: wild type
• Allele ID: MGI:2440056
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rpa1^tm1b(KOMP)Wtsi/Rpa1^+	C57BL/6N-Rpa1^tm1b(KOMP)Wtsi/J	MGI:5631499
ht2	Rpa1^tm1Wed/Rpa1^+	involves: 129/Sv * C57BL/6J * SJL	MGI:3590159

Genotype
MGI:5631499

ht1

• Allelic Composition: Rpa1^{tm1b(KOMP)Wtsi}/Rpa1⁺
• Genetic Background: C57BL/6N-Rpa1^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0395_5_A02

Data Sources

IMPC Data for Rpa1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:211773 )

IMPC - JAX

growth/size/body

increased heart weight ( J:211773 )

IMPC - JAX

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

♂

IMPC - JAX

decreased hematocrit ( J:211773 )

♂

IMPC - JAX

decreased hemoglobin content ( J:211773 )

♂

IMPC - JAX

increased mean corpuscular volume ( J:211773 )

IMPC - JAX

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

♂

IMPC - JAX

decreased circulating free fatty acids level ( J:211773 )

♂

IMPC - JAX

Genotype
MGI:3590159

ht2

• Allelic Composition: Rpa1^tm1Wed/Rpa1⁺
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

mortality/aging

premature death ( J:99303 )

• heterozygotes have significantly lower survival than their wild-type littermates with loss of heterozygotes beginning around 4 months, greater than 20% loss by 12 months, and about 60% loss by 2 years

neoplasm

increased lymphoma incidence ( J:99303 )

• 9 of 14 heterozygotes developed lymphomas and 4 of these were highly disseminated

immune system

increased lymphocyte cell number ( J:99303 )

• all heterozygotes between 4 and 14 months display marked lymphoid hyperplasia

cellular

chromosome breakage ( J:99303 )

• tumors in heterozygotes contain multiple chromosomal alterations with most showing gains of the entire chromosomes 6 and 15

• heterozygous MEFs have an increased frequency of abnormal karyotypes and chromosomal breaks and impaired double strand break repair

hematopoietic system

abnormal definitive hematopoiesis ( J:99303 )

• hematopoiesis in the bone marrow is abnormal

increased lymphocyte cell number ( J:99303 )

• all heterozygotes between 4 and 14 months display marked lymphoid hyperplasia