All Phenotypes Rxfp2<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rxfp2⁺
wild type
MGI:2440045

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cav1^tm1.1Aia/Cav1^tm1.1Aia Rxfp2^tm1Aia/Rxfp2⁺	involves: 129S7/SvEvBrd * C57BL/6J * FVB	MGI:5141501
cx2	Rxfp2^tm1Aia/crsp	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N	MGI:3603529

Allelic Composition	Cav1^tm1.1Aia/Cav1^tm1.1Aia Rxfp2^tm1Aia/Rxfp2⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cav1^tm1.1Aia mutation (0 available); any Cav1 mutation (33 available)
Rxfp2^tm1Aia mutation (0 available); any Rxfp2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:174719 )

N	• female mice are fertile

increased endometrial gland number ( J:174719 )

• mice exhibit an increase in the number of endometrial glands compared with wild-type mice

enlarged endometrial glands ( J:174719 )

ovary cyst ( J:174719 )

• in 6% of mice at 11 to 13 months

uterus cyst ( J:174719 )

• in 24% of mice at 5 to 7 months

• in 58% of mice at 11 to 13 months

abnormal uterus physiology ( J:174719 )

• endometrial glandular epithelium in mice with cysts exhibit increased proliferation compared to in wild-type mice

neoplasm

neoplasm ( J:174719 )

N	• mice do not develop endometrial cancer or metastases

endocrine/exocrine glands

increased endometrial gland number ( J:174719 )

• mice exhibit an increase in the number of endometrial glands compared with wild-type mice

enlarged endometrial glands ( J:174719 )

ovary cyst ( J:174719 )

• in 6% of mice at 11 to 13 months

growth/size/body

ovary cyst ( J:174719 )

• in 6% of mice at 11 to 13 months

uterus cyst ( J:174719 )

• in 24% of mice at 5 to 7 months

• in 58% of mice at 11 to 13 months

Allelic Composition	Rxfp2^tm1Aia/crsp
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
crsp mutation (0 available); any crsp mutation (0 available)
Rxfp2^tm1Aia mutation (0 available); any Rxfp2 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

azoospermia ( J:79124 )

• absence of spermatids and mature sperm

reproductive system

azoospermia ( J:79124 )

• absence of spermatids and mature sperm

small testis ( J:79124 )

bilateral cryptorchism ( J:79124 )

• bilaterally undescended testis located in the high intraabdominal position

arrest of spermatogenesis ( J:79124 )

abnormal gubernaculum morphology ( J:79124 )

• extended gubernaculum

absent male inguinal canal ( J:79124 )

• inguinal canal fails to form

male infertility ( J:79124 )

endocrine/exocrine glands

small testis ( J:79124 )

bilateral cryptorchism ( J:79124 )

• bilaterally undescended testis located in the high intraabdominal position

skeleton

abnormal gubernaculum morphology ( J:79124 )

• extended gubernaculum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cryptorchidism		DOID:11383	OMIM:219050	J:79124

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/06/2026 MGI 6.24