Phenotypes associated with this allele

• Allele Symbol: Dgcr8⁺
• Allele Name: wild type
• Allele ID: MGI:2440001
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	\Dgcr8^Gt(XG058)Byg/\Dgcr8^+	B6.129P2-Dgcr8^Gt(XG058)Byg	MGI:5559172
ht2	\Dgcr8^Gt(XH157)Byg/\Dgcr8^+	B6.129P2-Dgcr8^Gt(XH157)Byg	MGI:5451009
ht3	\Dgcr8^Gt(XG058)Byg/\Dgcr8^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5522556
ht4	\Dgcr8^Gt(XH157)Byg/\Dgcr8^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3802830
cx5	\Dgcr8^Gt(XH157)Byg/\Dgcr8^+ \Tg(Thy1-EGFP)MJrs/0	involves: 129P2/OlaHsd * C57BL/6J * CBA	MGI:3802829

Genotype
MGI:5559172

ht1

• Allelic Composition: \Dgcr8^Gt(XG058)Byg/\Dgcr8⁺
• Genetic Background: B6.129P2-Dgcr8^Gt(XG058)Byg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuronal migration ( J:201966 )

• decrease in the chemotactic responsiveness of medial ganglionic eminence derived cells to CXCL12

• migration defect in dentate precursor cells in the hippocampus

abnormal brain interneuron morphology ( J:201966 )

• distribution is altered at E18.5

decreased dentate gyrus size ( J:201966 )

• decrease in volume at P0

cellular

abnormal neuronal migration ( J:201966 )

• decrease in the chemotactic responsiveness of medial ganglionic eminence derived cells to CXCL12

• migration defect in dentate precursor cells in the hippocampus

Genotype
MGI:5451009

ht2

• Allelic Composition: \Dgcr8^Gt(XH157)Byg/\Dgcr8⁺
• Genetic Background: B6.129P2-Dgcr8^Gt(XH157)Byg

nervous system

enhanced long-term potentiation ( J:190908 )

• increased at 16 weeks of age but not at 8-10 weeks of age

• however, basal synaptic transmission is normal

Genotype
MGI:5522556

ht3

• Allelic Composition: \Dgcr8^Gt(XG058)Byg/\Dgcr8⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

behavior/neurological

behavior/neurological phenotype ( J:198659 )

N • mice exhibit normal locomotor activity in an open field test

impaired spatial learning ( J:198659 )

♂ • male mice exhibit impaired performance in the Morris Water maze compared with wild-type mice

abnormal spatial working memory ( J:198659 )

♂ • male, but not female, mice exhibit reduced spontaneous alternation in a Y-maze compared with wild-type mice

♂ • however, number of arm entries is normal and treatment with IGF2 rescues phenotype

behavioral despair ( J:198659 )

♂ • male mice exhibit increased immobility in a forced swim test compared with wild-type mice

abnormal nest building behavior ( J:198659 )

• impaired

nervous system

nervous system phenotype ( J:198659 )

N • mice exhibit normal morphological development of the brain

N • mice exhibit normal apoptosis in the lateral ventricle and hippocampal dentate gyrus

abnormal neuronal precursor proliferation ( J:198659 )

• adult neural progenitor cells exhibit decreased proliferation in the hippocampal dentate gyrus compared to in wild-type mice

• IGF2-stimulated neural progenitor cell proliferation is increased in vitro and in vivo compared with wild-type cell

• however, proliferation in the subventricular zone is normal

cellular

abnormal neuronal precursor proliferation ( J:198659 )

• adult neural progenitor cells exhibit decreased proliferation in the hippocampal dentate gyrus compared to in wild-type mice

• IGF2-stimulated neural progenitor cell proliferation is increased in vitro and in vivo compared with wild-type cell

• however, proliferation in the subventricular zone is normal

Genotype
MGI:3802830

ht4

• Allelic Composition: \Dgcr8^Gt(XH157)Byg/\Dgcr8⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

behavior/neurological

abnormal spatial working memory ( J:136969 )

• mice exhibit decreased arm choice accuracy compared to wild-type mice

nervous system

abnormal dendrite morphology ( J:136969 )

• mice exhibit a reduction in the number of dendritic spines and mushroom spine dendritic complexity of CA1 pyramidal neurons compared to in wild-type mice

decreased prepulse inhibition ( J:136969 )

• mice exhibit a deficit in prepulse inhibition compared to in wild-type mice

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:136969 )

N • despite abnormal prepulse inhibition, mice exhibit normal hearing

Genotype
MGI:3802829

cx5

• Allelic Composition: \Dgcr8^Gt(XH157)Byg/\Dgcr8⁺; \Tg(Thy1-EGFP)MJrs/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA

nervous system

abnormal dendrite morphology ( J:136969 )

• while length is normal, mushroom spine width in the CA1 pyramidal spines is decreased compared to in wild-type mice

• complexity of the basal dendritic tree of pyramidal neurons is reduced compared to in wild-type mice