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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dgcr8+
wild type
MGI:2440001
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Dgcr8Gt(XG058)Byg/Dgcr8+ B6.129P2-Dgcr8Gt(XG058)Byg MGI:5559172
ht2
 		Dgcr8Gt(XH157)Byg/Dgcr8+ B6.129P2-Dgcr8Gt(XH157)Byg MGI:5451009
ht3
 		Dgcr8Gt(XG058)Byg/Dgcr8+ involves: 129P2/OlaHsd * C57BL/6 MGI:5522556
ht4
 		Dgcr8Gt(XH157)Byg/Dgcr8+ involves: 129P2/OlaHsd * C57BL/6J MGI:3802830
cx5
 		Dgcr8Gt(XH157)Byg/Dgcr8+
Tg(Thy1-EGFP)MJrs/0 		involves: 129P2/OlaHsd * C57BL/6J * CBA MGI:3802829


Genotype
MGI:5559172
ht1
Allelic
Composition		 Dgcr8Gt(XG058)Byg/Dgcr8+
Genetic
Background		 B6.129P2-Dgcr8Gt(XG058)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8Gt(XG058)Byg mutation (1 available); any Dgcr8 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal migration ( J:201966 )
• decrease in the chemotactic responsiveness of medial ganglionic eminence derived cells to CXCL12
• migration defect in dentate precursor cells in the hippocampus
abnormal brain interneuron morphology ( J:201966 )
• distribution is altered at E18.5
decreased dentate gyrus size ( J:201966 )
• decrease in volume at P0

cellular
abnormal neuronal migration ( J:201966 )
• decrease in the chemotactic responsiveness of medial ganglionic eminence derived cells to CXCL12
• migration defect in dentate precursor cells in the hippocampus




Genotype
MGI:5451009
ht2
Allelic
Composition		 Dgcr8Gt(XH157)Byg/Dgcr8+
Genetic
Background		 B6.129P2-Dgcr8Gt(XH157)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8Gt(XH157)Byg mutation (1 available); any Dgcr8 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
enhanced long-term potentiation ( J:190908 )
• increased at 16 weeks of age but not at 8-10 weeks of age
• however, basal synaptic transmission is normal




Genotype
MGI:5522556
ht3
Allelic
Composition		 Dgcr8Gt(XG058)Byg/Dgcr8+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8Gt(XG058)Byg mutation (1 available); any Dgcr8 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:198659 )
N
• mice exhibit normal locomotor activity in an open field test
impaired spatial learning ( J:198659 )
• male mice exhibit impaired performance in the Morris Water maze compared with wild-type mice
abnormal spatial working memory ( J:198659 )
• male, but not female, mice exhibit reduced spontaneous alternation in a Y-maze compared with wild-type mice
• however, number of arm entries is normal and treatment with IGF2 rescues phenotype
behavioral despair ( J:198659 )
• male mice exhibit increased immobility in a forced swim test compared with wild-type mice

nervous system
nervous system phenotype ( J:198659 )
N
• mice exhibit normal morphological development of the brain
• mice exhibit normal apoptosis in the lateral ventricle and hippocampal dentate gyrus
abnormal neuronal precursor proliferation ( J:198659 )
• adult neural progenitor cells exhibit decreased proliferation in the hippocampal dentate gyrus compared to in wild-type mice
• IGF2-stimulated neural progenitor cell proliferation is increased in vitro and in vivo compared with wild-type cell
• however, proliferation in the subventricular zone is normal

cellular
abnormal neuronal precursor proliferation ( J:198659 )
• adult neural progenitor cells exhibit decreased proliferation in the hippocampal dentate gyrus compared to in wild-type mice
• IGF2-stimulated neural progenitor cell proliferation is increased in vitro and in vivo compared with wild-type cell
• however, proliferation in the subventricular zone is normal




Genotype
MGI:3802830
ht4
Allelic
Composition		 Dgcr8Gt(XH157)Byg/Dgcr8+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8Gt(XH157)Byg mutation (1 available); any Dgcr8 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spatial working memory ( J:136969 )
• mice exhibit decreased arm choice accuracy compared to wild-type mice

nervous system
abnormal dendrite morphology ( J:136969 )
• mice exhibit a reduction in the number of dendritic spines and mushroom spine dendritic complexity of CA1 pyramidal neurons compared to in wild-type mice
decreased prepulse inhibition ( J:136969 )
• mice exhibit a deficit in prepulse inhibition compared to in wild-type mice

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:136969 )
N
• despite abnormal prepulse inhibition, mice exhibit normal hearing




Genotype
MGI:3802829
cx5
Allelic
Composition		 Dgcr8Gt(XH157)Byg/Dgcr8+
Tg(Thy1-EGFP)MJrs/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgcr8Gt(XH157)Byg mutation (1 available); any Dgcr8 mutation (69 available)
Tg(Thy1-EGFP)MJrs mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dendrite morphology ( J:136969 )
• while length is normal, mushroom spine width in the CA1 pyramidal spines is decreased compared to in wild-type mice
• complexity of the basal dendritic tree of pyramidal neurons is reduced compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory