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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Espn+
wild type
MGI:2439588
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Espnje/Espn+ involves: fancier's dancing mouse MGI:3623766
ht2
Espnje/Espn+ JE/LeJ MGI:3698844
cx3
Cdh23v-2J/Cdh23+
Espnje/Espn+
(B6(V)-Cdh23v-2J/J x JE/LeJ)F1 MGI:4429960


Genotype
MGI:3623766
ht1
Allelic
Composition
Espnje/Espn+
Genetic
Background
involves: fancier's dancing mouse
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espnje mutation (2 available); any Espn mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
• hair cell pathology is present to varying degrees, sometimes scattered, and sometimes uniform along the entire organ of Corti
• at 12 months of age, stereocilia show loss of tonus, disarray, blunting and dispersion; the cuticular plate is sometimes split
• at 12 months of age, the stereocilia of the IHCs is frequently missing and replaecd with giant hair cells
• at 12 months of age, IHC loss is evely distributed along the organ of Corti
• at 12 months of age, outer hair cell loss occurs more frequently at the upper part of the cochlea that elsewhere
• in Espnje/+ mice ABR undergoes a progressive impairment with age, semiquantitatively correlated with pathology of the hair cells

nervous system
• hair cell pathology is present to varying degrees, sometimes scattered, and sometimes uniform along the entire organ of Corti
• at 12 months of age, stereocilia show loss of tonus, disarray, blunting and dispersion; the cuticular plate is sometimes split
• at 12 months of age, the stereocilia of the IHCs is frequently missing and replaecd with giant hair cells
• at 12 months of age, IHC loss is evely distributed along the organ of Corti
• at 12 months of age, outer hair cell loss occurs more frequently at the upper part of the cochlea that elsewhere




Genotype
MGI:3698844
ht2
Allelic
Composition
Espnje/Espn+
Genetic
Background
JE/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espnje mutation (2 available); any Espn mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear




Genotype
MGI:4429960
cx3
Allelic
Composition
Cdh23v-2J/Cdh23+
Espnje/Espn+
Genetic
Background
(B6(V)-Cdh23v-2J/J x JE/LeJ)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh23v-2J mutation (1 available); any Cdh23 mutation (274 available)
Espnje mutation (2 available); any Espn mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
N
• double heterozygotes do not have hearing impairment as determined by click tests and ABR threshold assessments





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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory