hearing/vestibular/ear
• hair cell pathology is present to varying degrees, sometimes scattered, and sometimes uniform along the entire organ of Corti
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• at 12 months of age, stereocilia show loss of tonus, disarray, blunting and dispersion; the cuticular plate is sometimes split
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• at 12 months of age, the stereocilia of the IHCs is frequently missing and replaecd with giant hair cells
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• at 12 months of age, IHC loss is evely distributed along the organ of Corti
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• at 12 months of age, outer hair cell loss occurs more frequently at the upper part of the cochlea that elsewhere
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• in Espnje/+ mice ABR undergoes a progressive impairment with age, semiquantitatively correlated with pathology of the hair cells
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nervous system
• hair cell pathology is present to varying degrees, sometimes scattered, and sometimes uniform along the entire organ of Corti
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• at 12 months of age, stereocilia show loss of tonus, disarray, blunting and dispersion; the cuticular plate is sometimes split
|
• at 12 months of age, the stereocilia of the IHCs is frequently missing and replaecd with giant hair cells
|
• at 12 months of age, IHC loss is evely distributed along the organ of Corti
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• at 12 months of age, outer hair cell loss occurs more frequently at the upper part of the cochlea that elsewhere
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