Analysis Tools|
Allele Symbol Allele Name Allele ID |
Krt71+ wild type MGI:2439581 |
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| Summary |
14 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• wavy coat
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• wavy vibrissae
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| N |
• auditory brainstem response analysis found no hearing deficit in two heterozygotes at 68 days of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hypotrichosis 13 | DOID:0110710 |
OMIM:615896 |
J:213988 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Phenotype of Krt71Mhdarco12/+ or Krt71Mhdarco12/Krt71Mhdarco12 and Krt71Mhdarco13/+ or Krt71Mhdarco13/Krt71Mhdarco13 mice.
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• curl visible by P10
• becomes less pronounced by 3 months of age
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• irregular formation of Henle's and Huxley's layers
• areas of increased thickness in Henle's layer are associated with round structures
• intermediate keratin filaments in Henle's layer form large whorls with short lengths of linear intermediate filament bundles
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Phenotype of Krt71Mhdarco12/+ or Krt71Mhdarco12/Krt71Mhdarco12 and Krt71Mhdarco13/+ or Krt71Mhdarco13/Krt71Mhdarco13 mice.
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• curl visible by P10
• becomes less pronounced by 3 months of age
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• irregular formation of Henle's and Huxley's layers
• areas of increased thickness in Henle's layer are associated with round structures
• intermediate keratin filaments in Henle's layer form large whorls with short lengths of linear intermediate filament bundles
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• evident when the first coat comes in, pronounced very wavy coat by 3 weeks of age, and ruffled coat persists but becomes less wavy with age
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• very curved vibrissae
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• seen as early as 2 weeks of age util the second hair cycle around 4 weeks of age after which the coat loses its waviness but still has a subtle abnormal appearance.
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• can be seen in mutant mice as early as one day of age
• whiskers are curved and grow irregularly
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• a clear ridge of hair grows down the center of the back and disappears by weaning
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• contributes to a ridge of hair down the center of the back of preweanling mice
• as mice age curling decreases and ridge disappears
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• seen as early as 2 weeks of age util the second hair cycle around 4 weeks of age after which the coat loses its waviness but still has a subtle abnormal appearance.
|
|
• can be seen in mutant mice as early as one day of age
• whiskers are curved and grow irregularly
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• extent is obvious from 2-4 weeks of age after which the wave is subtle
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• vibrissae are curved and grow mutlidirectionally rather than straight and parallel
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• evident at one day of age
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|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• seen as early as 2 weeks of age util the second hair cycle around 4 weeks of age after which the coat loses its waviness but still has a subtle abnormal appearance.
|
|
• can be seen in mutant mice as early as one day of age
• whiskers are curved and grow irregularly
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• extent is obvious from 2-4 weeks of age after which the wave is subtle
|
|
• vibrissae are curved and grow mutlidirectionally rather than straight and parallel
|
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• evident at one day of age
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|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• noticeable by two weeks of age
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• slight bend or wave in the whiskers
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| N |
• no defects were found in the eyes of two heterozygotes assessed at 3 months of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• more marked in the first pelage
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• curved and irregular in direction
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some mice display hairy and bald patches while others display a uniform caracul phenotype
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• some mice display hairy and bald patches while others display a uniform caracul phenotype
• within the hairy patches the hair is also curly
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 01/20/2026 MGI 6.24 |
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