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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fezf2+
wild type
MGI:2439352
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ephb1tm1Dgen/Ephb1tm1Dgen
Fezf2tm1Skm/Fezf2+ 		involves: 129 MGI:5767284
cx2
 		Fezf1tm1Hibi/Fezf1tm1Hibi
Fezf2tm1Hibi/Fezf2+ 		involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3767819


Genotype
MGI:5767284
cx1
Allelic
Composition		 Ephb1tm1Dgen/Ephb1tm1Dgen
Fezf2tm1Skm/Fezf2+
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb1tm1Dgen mutation (0 available); any Ephb1 mutation (45 available)
Fezf2tm1Skm mutation (0 available); any Fezf2 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon guidance ( J:214959 )
• at P7, a large proportion of PLAP-positive axons extended aberrantly to contralateral targets, crossing the midline via an enlarged anterior commissure, unlike in control mice where PLAP-positive axons are exclusively observed extending along ipsilateral, corticofugal trajectories
• a reduction of PLAP-positive axons is found in the cerebral peduncle and the cervical spinal cord, canonical targets of the corticospinal tract in wild-type mice
increased anterior commissure size ( J:214959 )
• enlarged anterior commissure at P7

cellular
abnormal axon guidance ( J:214959 )
• at P7, a large proportion of PLAP-positive axons extended aberrantly to contralateral targets, crossing the midline via an enlarged anterior commissure, unlike in control mice where PLAP-positive axons are exclusively observed extending along ipsilateral, corticofugal trajectories
• a reduction of PLAP-positive axons is found in the cerebral peduncle and the cervical spinal cord, canonical targets of the corticospinal tract in wild-type mice




Genotype
MGI:3767819
cx2
Allelic
Composition		 Fezf1tm1Hibi/Fezf1tm1Hibi
Fezf2tm1Hibi/Fezf2+
Genetic
Background		 involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fezf1tm1Hibi mutation (0 available); any Fezf1 mutation (31 available)
Fezf2tm1Hibi mutation (0 available); any Fezf2 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory