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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spast+
wild type
MGI:2439136
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		SpastM1Gri/Spast+ B6.C-SpastM1Gri MGI:3847313
ht2
 		Spasttm1Jfnk/Spast+ involves: 129S1/Sv * 129X1/SvJ MGI:5492077
ht3
 		Spasttm1.1Jme/Spast+ involves: C57BL/6J MGI:3699156


Genotype
MGI:3847313
ht1
Allelic
Composition		 SpastM1Gri/Spast+
Genetic
Background		 B6.C-SpastM1Gri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SpastM1Gri mutation (0 available); any Spast mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:148877 )
• mice exhibit axonal swelling containing stalled cargoes in cortical neurons unlike in wild-type mice
• however, axonal branching is normal
abnormal axonal transport ( J:148877 )
• anterograde axonal transport of mitochondria is reduced 25% compared to in wild-type mice




Genotype
MGI:5492077
ht2
Allelic
Composition		 Spasttm1Jfnk/Spast+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spasttm1Jfnk mutation (1 available); any Spast mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired coordination ( J:94077 )
• variable impairment in rotarod and grid-walking analysis




Genotype
MGI:3699156
ht3
Allelic
Composition		 Spasttm1.1Jme/Spast+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spasttm1.1Jme mutation (0 available); any Spast mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon morphology ( J:117740 )
• axonal swellings are seen in the white matter of the spinal cord, although these are not as numerous as in homozygous mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory