All Phenotypes Ank1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ank1⁺
wild type
MGI:2439040

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ank1^M1Wlst/Ank1⁺	C3.B6-Ank1^M1Wlst	MGI:4948067
ht2	Ank1^M1Btlr/Ank1⁺	C57BL/6J-Ank1^m1Btlr	MGI:5528856
ht3	Ank1^ity16/Ank1⁺	involves: 129S1/Sv * 129X1/SvJ * DBA/2J	MGI:5502659
ht4	Ank1^Rbc2/Ank1⁺	involves: 129S1/Sv * BALB/c	MGI:3844299
ht5	Ank1^M1Wlst/Ank1⁺	involves: 129S1/SvImJ * C3H/HeJ * C57BL/6	MGI:4948065
ht6	Ank1^M1Wlst/Ank1⁺	involves: C3H/HeJ * C57BL/6	MGI:4948063
ht7	Ank1^nb/Ank1⁺	involves: C57BL/6J * WB/Re	MGI:3767057
ht8	Ank1^MRI23420/Ank1⁺	SJL/J-Ank1^MRI23420	MGI:5438703

Allelic Composition	Ank1^M1Wlst/Ank1⁺
Genetic Background	C3.B6-Ank1^M1Wlst

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^M1Wlst mutation (0 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased erythrocyte cell number ( J:170562 )

decreased cellular hemoglobin content ( J:170562 )

decreased mean corpuscular hemoglobin concentration ( J:170562 )

decreased mean corpuscular volume ( J:170562 )

polychromatophilia ( J:170562 )

reticulocytosis ( J:170562 )

increased erythrocyte osmotic fragility ( J:170562 )

Allelic Composition	Ank1^M1Btlr/Ank1⁺
Genetic Background	C57BL/6J-Ank1^m1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^M1Btlr mutation (1 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased erythrocyte cell number ( J:203831 )

decreased mean corpuscular hemoglobin ( J:203831 )

decreased mean corpuscular volume ( J:203831 )

hemolysis ( J:203831 )

increased erythrocyte osmotic fragility ( J:203831 )

• increased osmotic fragility

homeostasis/metabolism

increased circulating bilirubin level ( J:203831 )

Allelic Composition	Ank1^ity16/Ank1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^ity16 mutation (0 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Progression of lesions in kidney and liver after Salmonella infection of Ank1^ity16/Ank⁺ and Ank1^ity16/Ank1^ity16 mice

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:199427 )

• intermediate in mice infected with Salmonella Typhimurium

hematopoietic system

extramedullary hematopoiesis ( J:199427 )

• in the liver

increased erythrocyte cell number ( J:199427 )

• small in uninfected mice and mice infected with Salmonella Typhimurium

homeostasis/metabolism

increased kidney iron level ( J:199427 )

• in mice infected with Salmonella Typhimurium

increased liver iron level ( J:199427 )

• in mice infected with Salmonella Typhimurium

immune system

increased susceptibility to bacterial infection ( J:199427 )

• mice infected with Salmonella Typhimurium exhibit increased bacterial load in the spleen, liver and kidney and increased mortality compared with wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:199427 )

• intermediate in mice infected with Salmonella Typhimurium

liver/biliary system

increased liver iron level ( J:199427 )

• in mice infected with Salmonella Typhimurium

renal/urinary system

increased kidney iron level ( J:199427 )

• in mice infected with Salmonella Typhimurium

Allelic Composition	Ank1^Rbc2/Ank1⁺
Genetic Background	involves: 129S1/Sv * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^Rbc2 mutation (0 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:148127 )

• P. chabaudi-infected mice are resistant to malaria infection with increased survival compared with similarly treated wild-type mice

hematopoietic system

decreased mean corpuscular volume ( J:148127 )

increased erythrocyte osmotic fragility ( J:148127 )

immune system

decreased susceptibility to parasitic infection ( J:148127 )

• P. chabaudi-infected mice are resistant to malaria infection with increased survival compared with similarly treated wild-type mice

Allelic Composition	Ank1^M1Wlst/Ank1⁺
Genetic Background	involves: 129S1/SvImJ * C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^M1Wlst mutation (0 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:170562 )

abnormal erythrocyte morphology ( J:170562 )

• mice exhibit the same red blood cell phenotypes observed on a congenic C3H background

immune system

enlarged spleen ( J:170562 )

growth/size/body

enlarged spleen ( J:170562 )

Allelic Composition	Ank1^M1Wlst/Ank1⁺
Genetic Background	involves: C3H/HeJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^M1Wlst mutation (0 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased erythrocyte cell number ( J:170562 )

decreased cellular hemoglobin content ( J:170562 )

decreased mean corpuscular volume ( J:170562 )

Allelic Composition	Ank1^nb/Ank1⁺
Genetic Background	involves: C57BL/6J * WB/Re

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^nb mutation (2 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal erythrocyte morphology ( J:111131 )

• occasional deformed erythrocytes are found in heterozygotes

increased erythrocyte protoporphyrin level ( J:5985 )

• red blood cells show a higher concentration of protoporphyrin than in wild-type

homeostasis/metabolism

increased erythrocyte protoporphyrin level ( J:5985 )

• red blood cells show a higher concentration of protoporphyrin than in wild-type

immune system

decreased susceptibility to parasitic infection ( J:111131 )

• lower peak parasitaemia when infected with Plasmodium chabaudi, but normal lethal infection level occurs when infected with P. berghei

Allelic Composition	Ank1^MRI23420/Ank1⁺
Genetic Background	SJL/J-Ank1^MRI23420

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^MRI23420 mutation (1 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Microcytosis in Ank1^MRI23420/Ank1⁺ mice and spherocytosis and jaundice in Ank1^MRI23420/Ank1^MRI23420 mice

growth/size/body

enlarged spleen ( J:187820 )

• slight

increased spleen weight ( J:187820 )

mortality/aging

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:187820 )

• following malaria infection

hematopoietic system

anemia ( J:187820 )

abnormal erythrocyte morphology ( J:187820 )

• small with membrane bledding

increased erythrocyte cell number ( J:187820 )

polycythemia ( J:187820 )

• mild

decreased mean corpuscular hemoglobin ( J:187820 )

decreased mean corpuscular volume ( J:187820 )

hyperchromasia ( J:187820 )

microcytosis ( J:187820 )

thrombocytosis ( J:187820 )

abnormal spleen morphology ( J:187820 )

• reduced medulla and proliferation of the extramedullary compartment

enlarged spleen ( J:187820 )

• slight

increased spleen weight ( J:187820 )

increased spleen iron level ( J:187820 )

• 2-fold in the extramedullary compartment

increased erythrocyte osmotic fragility ( J:187820 )

• lyse at higher salt concentrations than wild-type cells

homeostasis/metabolism

increased spleen iron level ( J:187820 )

• 2-fold in the extramedullary compartment

immune system

abnormal spleen morphology ( J:187820 )

• reduced medulla and proliferation of the extramedullary compartment

enlarged spleen ( J:187820 )

• slight

increased spleen weight ( J:187820 )

increased spleen iron level ( J:187820 )

• 2-fold in the extramedullary compartment

decreased susceptibility to parasitic infection ( J:187820 )

• mice are resistant to malaria infection with reduced proportion of infected red blood cells, increased splenic clearance of red blood cells, increased intraerythrocytic parasite death and reduced mortality compared with wild-type mice

decreased susceptibility to parasitic infection induced morbidity/mortality ( J:187820 )

• following malaria infection

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