Analysis Tools|
Allele Symbol Allele Name Allele ID |
Sart3+ wild type MGI:2438878 |
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| Summary |
2 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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IMPC - BCM
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IMPC - BCM
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IMPC - BCM
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IMPC - BCM
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hematopoietic progenitor cells (HPCs) in the bone marrow and spleen are slowly or noncycling compared to in wild-type mice
• HPCs from 5-FU-treated mice are more protected than HPCs from wild-type mice
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• mice exhibit decreased colony forming units granulocyte, erythrocyte, macrophage, and megakaryocyte (CFU-GEMM) and granulocyte-macrophage (CFU-GM) compared with wild-type mice
• 5-FU-treated mice fail to exhibit a decrease in CFU-GM numbers by day 7 unlike similarly treated wild-type mice
• 5-FU-treated mice exhibit a 14.1-fold increase in CFU-GM at day 11 compared with a 5-fold elevation in similarly treated mice
• 5-FU-treated mice exhibit restored CFU-GEMM numbers after 11 days unlike similarly treated wild-type mice
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• mice exhibit decreased blast forming units erythrocyte (BFU-E) compared with wild-type mice
• 5-FU-treated mice exhibit a 1.9-fold increase in BFU-E unlike similarly treated wild-type mice
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• 5-FU-treated mice exhibit a decrease in long and short term repopulating hematopoietic stem cells compared with similarly treated wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/25/2025 MGI 6.24 |
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