All Phenotypes Chek2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Chek2⁺
wild type
MGI:2438760

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Chek2^tm1Mak/Chek2⁺ Rad50^tm2Jpt/Rad50^tm2Jpt	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:3615685

Allelic Composition	Chek2^tm1Mak/Chek2⁺ Rad50^tm2Jpt/Rad50^tm2Jpt
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chek2^tm1Mak mutation (1 available); any Chek2 mutation (52 available)
Rad50^tm2Jpt mutation (0 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:103922 )

• 31 of 41 die by 5 months of age

hematopoietic system

abnormal pro-B cell morphology ( J:103922 )

• pro-B cell numbers are similar to that in homozygous Rad50^tm2Jpt mice

decreased double-negative T cell number ( J:103922 )

• double-negative T cell numbers are similar to that in homozygous Rad50^tm2Jpt mice

anemia ( J:103922 )

• 36 of 41 develop anemia

decreased macrophage cell number ( J:103922 )

• macrophage numbers are similar to that in homozygous Rad50^tm2Jpt mice

immune system