Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ddb2+ wild type MGI:2438754 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% and 100% of mice develop squamous cell carcinomas at weeks 11 and 15, respectively, whereas wild-type mice develop similar percentages at weeks 16 and 20, respectively, following a daily dose of 250 J/m2
• yields of squamous cell carcinomas larger than 1mm and 2mm are increased following a daily dose of 250 J/m2
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Tumorigenesis analysis and Hisptopathological images
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• mutants treated with UV light develop skin tumors at a similar time as wild-type, however once tumors form, tumor development proceeds at a greater rate and mice develop more tumors than controls
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• increased incidence of skin tumors after UV-irradiation
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| xeroderma pigmentosum group E | DOID:0110846 |
OMIM:278740 |
J:88125 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 70% (7 of 10) died between 20 and 26 months of age
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• broad spectrum of tumors found in mice dying between 20 and 26 months of age
• 3 of 7 dead mice had tumors of varying types
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| xeroderma pigmentosum group E | DOID:0110846 |
OMIM:278740 |
J:95633 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/25/2025 MGI 6.24 |
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