Phenotypes associated with this allele

• Allele Symbol: Cttnbp2⁺
• Allele Name: wild type
• Allele ID: MGI:2438710
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cttnbp2^em1Yph/Cttnbp2^+	C57BL/6-Cttnbp2^em1Yph	MGI:6694209
ht2	Cttnbp2^em2Yph/Cttnbp2^+	C57BL/6-Cttnbp2^em2Yph	MGI:6694223
cx3	Cttnbp2^em1Yph/Cttnbp2^+ Tg(Thy1-YFP)HJrs/0	B6.Cg-Cttnbp2^em1Yph Tg(Thy1-YFP)HJrs	MGI:6694271
cx4	Cttnbp2^em2Yph/Cttnbp2^+ Tg(Thy1-YFP)HJrs/0	B6.Cg-Cttnbp2^em2Yph Tg(Thy1-YFP)HJrs	MGI:6694273

Genotype
MGI:6694209

ht1

• Allelic Composition: Cttnbp2^em1Yph/Cttnbp2⁺
• Genetic Background: C57BL/6-Cttnbp2^em1Yph

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired learning ( J:300704 )

• in an appetitively motivated T-maze assay, mice are able to learn and memorize the correct arm to obtain the reward, but mice need more trials to relearn that the reward had been switched to the other arm, indicating impaired reversal learning

abnormal response to social novelty ( J:300704 )

• in the second session of the 3-chamber test, mice show no preference for stranger 2 compared to stranger 1, indicating defective novelty preference

Genotype
MGI:6694223

ht2

• Allelic Composition: Cttnbp2^em2Yph/Cttnbp2⁺
• Genetic Background: C57BL/6-Cttnbp2^em2Yph

behavior/neurological

abnormal response to social novelty ( J:300704 )

• in the reciprocal social interaction test, mice spend less time interacting with strangers

• in the 3-chamber test, mice show impaired novelty preference, with less obvious preference for stranger 2 versus stranger 1, however no effect on sociability is seen

• zinc supplementation ameliorates the social deficits in the reciprocal social interaction test, with mice spending significantly longer interacting with the unfamiliar mouse

• treatment with D-cycloserine, a co-agonist of NMDAR, improved social interaction in the reciprocal social interaction test to wild-type levels

• however, mice behave normally in the open field and elevated plus maze

decreased vocalization ( J:300704 )

• isolated pups exhibit shorter call duration, reduced calling frequency, and longer latency to have the first call at P6 but not P8

homeostasis/metabolism

decreased brain zinc level ( J:300704 )

nervous system

decreased brain zinc level ( J:300704 )

Genotype
MGI:6694271

cx3

• Allelic Composition: Cttnbp2^em1Yph/Cttnbp2⁺; Tg(Thy1-YFP)HJrs/0
• Genetic Background: B6.Cg-Cttnbp2^em1Yph Tg(Thy1-YFP)HJrs

nervous system

abnormal dendritic spine morphology ( J:300704 )

• dorsal CA1 neurons have smaller width of dendritic spine heads

Genotype
MGI:6694273

cx4

• Allelic Composition: Cttnbp2^em2Yph/Cttnbp2⁺; Tg(Thy1-YFP)HJrs/0
• Genetic Background: B6.Cg-Cttnbp2^em2Yph Tg(Thy1-YFP)HJrs

nervous system

abnormal dendritic spine morphology ( J:300704 )

• dorsal CA1 neurons have reduced density and width of dendritic spines

decreased dendritic spine density ( J:300704 )

• dorsal CA1 neurons have reduced density of dendritic spines