All Phenotypes Eif4e<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Eif4e⁺
wild type
MGI:2438679

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Eif4e^{Tn(pb-Act-RFP)1Xwu}/Eif4e⁺	involves: FVB/NJ	MGI:7738547
cx2	Eif4e^{Gt(RRO036)Byg}/Eif4e⁺ Kras^tm3Tyj/Kras⁺	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N	MGI:5708384

Allelic Composition	Eif4e^{Tn(pb-Act-RFP)1Xwu}/Eif4e⁺
Genetic Background	involves: FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4e^{Tn(pb-Act-RFP)1Xwu} mutation (0 available); any Eif4e mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:308879 )

• at 4 weeks of age, the body weight of heterozygous pups resulting from heterozygous cross-matings is significantly lower than that of wild-type littermates

embryo

embryo phenotype ( J:308879 )

N	• heterozygous embryos develop normally past the implantation stage and mice are viable

Allelic Composition	Eif4e^{Gt(RRO036)Byg}/Eif4e⁺ Kras^tm3Tyj/Kras⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4e^{Gt(RRO036)Byg} mutation (0 available); any Eif4e mutation (40 available)
Kras^tm3Tyj mutation (1 available); any Kras mutation (69 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:224214 )

• smaller tumors of mice treated with piperlongumine than in Kras^tm3Tyj heterozygotes

decreased lung tumor incidence ( J:224214 )

• fewer tumors by 12 weeks with a more than 2-fold reduction in tumor burden compared with Kras^tm3Tyj heterozygotes

cellular

increased cellular sensitivity to oxidative stress ( J:224214 )

• in tumors of mice treated with piperlongumine

oxidative stress ( J:224214 )

• increased compared with Kras^tm3Tyj heterozygotes

respiratory system

decreased lung tumor incidence ( J:224214 )

• fewer tumors by 12 weeks with a more than 2-fold reduction in tumor burden compared with Kras^tm3Tyj heterozygotes

homeostasis/metabolism

increased cellular sensitivity to oxidative stress ( J:224214 )

• in tumors of mice treated with piperlongumine

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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