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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Srr+
wild type
MGI:2438593
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		SrrRgsc34/Srr+ involves: C57BL/6JJcl * DBA/2JJcl MGI:3798497
ht2
 		Srrtm1.2Jtc/Srr+ involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:4438924


Genotype
MGI:3798497
ht1
Allelic
Composition		 SrrRgsc34/Srr+
Genetic
Background		 involves: C57BL/6JJcl * DBA/2JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SrrRgsc34 mutation (1 available); any Srr mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal neutrophil physiology ( J:133634 )
• neutrophils of mice heterozygous for this mutation exhibit reduced peroxidase activity (MPXI) (-16.2% vs. the control range of -11.99 to -7.71%)

hematopoietic system
abnormal neutrophil physiology ( J:133634 )
• neutrophils of mice heterozygous for this mutation exhibit reduced peroxidase activity (MPXI) (-16.2% vs. the control range of -11.99 to -7.71%)




Genotype
MGI:4438924
ht2
Allelic
Composition		 Srrtm1.2Jtc/Srr+
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srrtm1.2Jtc mutation (0 available); any Srr mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain morphology ( J:158266 )
• cortical D-serine levelsare approximately 70% of wild-type
increased excitatory postsynaptic current amplitude ( J:158266 )
• perfusion of hippocampal containing coronal slices with D-serine (10 M) induced an 81% increase in the amplitude of pharmacologically isolated NMDAR current compared to a 41.8% increase in wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory