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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Spo11+
wild type
MGI:2438387
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Spo11tm1Mjn/Spo11+ B6.Cg-Spo11tm1Mjn MGI:6506424
cx2
Spo11tm1Mjn/Spo11+
Stag3tm1e.1(KOMP)Wtsi/Stag3tm1e.1(KOMP)Wtsi
B6.Cg-Spo11tm1Mjn Stag3tm1e.1(KOMP)Wtsi/2J MGI:6506426


Genotype
MGI:6506424
ht1
Allelic
Composition
Spo11tm1Mjn/Spo11+
Genetic
Background
B6.Cg-Spo11tm1Mjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• reduced number of double-strand DNA breaks (67% of WT) in zygotene spermatocytes

homeostasis/metabolism
• reduced number of double-strand DNA breaks (67% of WT) in zygotene spermatocytes




Genotype
MGI:6506426
cx2
Allelic
Composition
Spo11tm1Mjn/Spo11+
Stag3tm1e.1(KOMP)Wtsi/Stag3tm1e.1(KOMP)Wtsi
Genetic
Background
B6.Cg-Spo11tm1Mjn Stag3tm1e.1(KOMP)Wtsi/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (21 available)
Stag3tm1e.1(KOMP)Wtsi mutation (1 available); any Stag3 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• complete absence of double-strand DNA breaks in 77% of zygotene spermatocytes and 50% reduction (compared to either single KO) in remaining 23% of spermatocytes

homeostasis/metabolism
• complete absence of double-strand DNA breaks in 77% of zygotene spermatocytes and 50% reduction (compared to either single KO) in remaining 23% of spermatocytes





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory