Phenotypes associated with this allele

• Allele Symbol: Foxa1⁺
• Allele Name: wild type
• Allele ID: MGI:2438343
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Foxa1^tm1Gsc/Foxa1^+	involves: 129P2/OlaHsd	MGI:4461462
ht2	Foxa1^tm1Stf/Foxa1^+	Not Specified	MGI:3806681
cn3	Foxa1^tm1Khk/Foxa1^+ Foxa2^tm1Khk/Foxa2^tm1Khk Tg(Pdx1-cre)6Cvw/0	involves: 129 * C57BL/6 * CBA * SJL	MGI:3831162
cn4	Foxa1^tm1(cre)Sew/Foxa1^+ Mst1r^tm1Sew/Mst1r^tm1Sew	involves: 129P2/OlaHsd * CD-1 * NIH Black Swiss	MGI:3806707

Genotype
MGI:4461462

ht1

• Allelic Composition: Foxa1^tm1Gsc/Foxa1⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:161401 )

♀ • significant decrease in ductal invasion at both mid-puberty (5 weeks) and late puberty (7 weeks)

♀ • ovariectomy and estradiol plus progesterone replacement do not rescue the defect

increased mammary gland apoptosis ( J:161401 )

♀ • increased epithelial apoptosis in mammary glands from 5-week-old mice

♀ • normal proliferation

integument

abnormal branching of the mammary ductal tree ( J:161401 )

♀ • significant decrease in ductal invasion at both mid-puberty (5 weeks) and late puberty (7 weeks)

♀ • ovariectomy and estradiol plus progesterone replacement do not rescue the defect

increased mammary gland apoptosis ( J:161401 )

♀ • increased epithelial apoptosis in mammary glands from 5-week-old mice

♀ • normal proliferation

Genotype
MGI:3806681

ht2

• Allelic Composition: Foxa1^tm1Stf/Foxa1⁺
• Genetic Background: Not Specified

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:138581 )

• plasma alpha HDL, pre-beta HDL and overall HDL are decreased compared to in wild-type mice

Genotype
MGI:3831162

cn3

• Allelic Composition: Foxa1^tm1Khk/Foxa1⁺; Foxa2^tm1Khk/Foxa2^tm1Khk; Tg(Pdx1-cre)6Cvw/0
• Genetic Background: involves: 129 * C57BL/6 * CBA * SJL

mortality/aging

postnatal lethality, complete penetrance ( J:143476 )

• mice die prior to P5

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:143476 )

pancreatic islet hypoplasia ( J:143476 )

pancreas hypoplasia ( J:143476 )

• the pancreas occupies 31% relative area compared to in wild-type mice

exocrine pancreas hypoplasia ( J:143476 )

digestive/alimentary system

exocrine pancreas hypoplasia ( J:143476 )

Genotype
MGI:3806707

cn4

• Allelic Composition: Foxa1^tm1(cre)Sew/Foxa1⁺; Mst1r^tm1Sew/Mst1r^tm1Sew
• Genetic Background: involves: 129P2/OlaHsd * CD-1 * NIH Black Swiss

immune system

decreased susceptibility to bacterial infection ( J:105979 )

• following intraperitoneal injection of LPS and Gal-N, mice exhibit protection from liver damage along with improved histology, reduced serum alanine aminotransferase levels, reduced hepatocyte apoptosis, a 3.5-fold elevation in TNF-alpha serum levels 3 hours after injection, a 64% reduction in IFN-gamma serum levels, a 71% reduction in IL10 serum levels, and a 1 to 2 hour delay in progression to death compared to in similarly treated wild-type mice