Analysis Tools|
Allele Symbol Allele Name Allele ID |
Fto+ wild type MGI:2438303 |
| Summary |
2 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice have less weight gain and less body-fat percentage than controls after 12 weeks on a high-fat diet
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• mice have less weight gain and less body-fat percentage than controls after 12 weeks on a high-fat diet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in 18 week old male mice
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• in 18 week old male mice
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• 18 week old male mice exhibit increased respiratory exchange rate compared with similarly treated wild-type mice
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• whole body metabolism in male is increased with a switch to relatively more carbohydrate metabolism than in wild-type mice
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• beginning at 12 weeks, male mice exhibit a maturity-onset reduction in body weight compared with wild-type mice
• at 24 weeks, male mice weigh 10% less than wild-type mice
• however, female mice maintain normal body weight
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• at 24 weeks, male mice exhibit a 16% to 18% decrease in total fat mass compared with wild-type mice
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• in 24 week old male mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/25/2025 MGI 6.24 |
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