All Phenotypes Map3k8<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Map3k8⁺
wild type
MGI:2438233

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Map3k8^M1Btlr/Map3k8⁺	C57BL/6J-Map3k8^M1Btlr	MGI:3817421
ht2	Map3k8^m3Btlr/Map3k8⁺	C57BL/6J-Map3k8^m3Btlr	MGI:5688648
ht3	Map3k8^M4Btlr/Map3k8⁺	C57BL/6J-Map3k8^M4Btlr	MGI:6113559

Allelic Composition	Map3k8^M1Btlr/Map3k8⁺
Genetic Background	C57BL/6J-Map3k8^M1Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8^M1Btlr mutation (1 available); any Map3k8 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:140986 )

• only ~25% of the expected number of heterozygous mutant mice are born; the developmental stage at which death occurs has not been determined

• surviving heterozygotes exhibit no overt phenotypic defects, are viable, and can breed

immune system

abnormal tumor necrosis factor secretion ( J:140986 )

• heterozygous macrophages secrete somewhat diminished levels of TNF-alpha in response to lower doses of the TLR1/2 ligand Pam3SK4, but slightly elevated levels in response to higher doses

decreased tumor necrosis factor secretion ( J:140986 )

• peritoneal macrophages from mice heterozygous for this mutation exhibit impairment in TNF-alpha secretion in response to MALP2 and PGN signaling via TLR1/2, CpG-DNA signaling via TLR9, and LPS signaling via TLR4

• resiquimod signaling via TLR7 stimulates statistically normal TNF-alpha secretion by heterozygous mutant macrophages

Allelic Composition	Map3k8^m3Btlr/Map3k8⁺
Genetic Background	C57BL/6J-Map3k8^m3Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8^m3Btlr mutation (0 available); any Map3k8 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased macrophage cytokine production ( J:224668 )

• some mice show reduced TNFalpha secretion in response to the Toll-like receptor ligands CpG oligodeoxynucleotide (TLR9), lipopolysaccharide (TLR4), Pam3CSK4 (TLR1/2), and poly(I:C) (TLR3)

decreased tumor necrosis factor secretion ( J:224668 )

• some mice show reduced TNFalpha secretion in response to the Toll-like receptor ligands CpG oligodeoxynucleotide (TLR9), lipopolysaccharide (TLR4), Pam3CSK4 (TLR1/2), and poly(I:C) (TLR3)

hematopoietic system

decreased macrophage cytokine production ( J:224668 )

• some mice show reduced TNFalpha secretion in response to the Toll-like receptor ligands CpG oligodeoxynucleotide (TLR9), lipopolysaccharide (TLR4), Pam3CSK4 (TLR1/2), and poly(I:C) (TLR3)

Allelic Composition	Map3k8^M4Btlr/Map3k8⁺
Genetic Background	C57BL/6J-Map3k8^M4Btlr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k8^M4Btlr mutation (0 available); any Map3k8 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased tumor necrosis factor secretion ( J:254880 )

• reduced TNFalpha secretion in response to the Toll-like receptor ligand lipopolysaccharide

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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