All Phenotypes Vgf<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Vgf⁺
wild type
MGI:2438089

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Vgf^tm1Srjs/Vgf⁺	B6.129-Vgf^tm1Srjs	MGI:3828160
ht2	Vgf^tm1Vlcg/Vgf⁺	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac	MGI:5688362

Allelic Composition	Vgf^tm1Srjs/Vgf⁺
Genetic Background	B6.129-Vgf^tm1Srjs

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vgf^tm1Srjs mutation (0 available); any Vgf mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:143370 )

• mice exhibit decreased freezing in a contextual fear conditioning assay compared to wild-type mice

Allelic Composition	Vgf^tm1Vlcg/Vgf⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vgf^tm1Vlcg mutation (0 available); any Vgf mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal adrenal medulla morphology ( J:212045 )

• at 6-8 weeks of age, Western blot analysis revealed that chromogranin B (CgB) protein levels in the adrenal medulla are reduced to 68.7% of wild-type levels

• in contrast, adrenal chromogranin A, and secretogranin II and III levels are not significantly altered

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