Phenotypes associated with this allele

• Allele Symbol: Spop⁺
• Allele Name: wild type
• Allele ID: MGI:2437935
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Spop^tm1b(KOMP)Wtsi/Spop^+	C57BL/6N-Spop^tm1b(KOMP)Wtsi/Tcp	MGI:5757763
ht2	Spop^Gt(BGB118)Byg/Spop^+	involves: 129P2/OlaHsd * C57BL/6	MGI:4837258
cx3	Pdx1^tm1Cvw/Pdx1^+ Spop^Gt(BGB118)Byg/Spop^+	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4837259

Genotype
MGI:5757763

ht1

• Allelic Composition: Spop^{tm1b(KOMP)Wtsi}/Spop⁺
• Genetic Background: C57BL/6N-Spop^{tm1b(KOMP)Wtsi}/Tcp
• Cell Lines: EPD0205_5_D01

Data Sources

IMPC Data for Spop

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased food intake ( J:211773 )

♂

IMPC - TCP

decreased grip strength ( J:211773 )

♀

IMPC - TCP

endocrine/exocrine glands

small adrenal glands ( J:211773 )

♂

IMPC - TCP

small thymus ( J:211773 )

♂

IMPC - TCP

hematopoietic system

small thymus ( J:211773 )

♂

IMPC - TCP

homeostasis/metabolism

increased circulating aspartate transaminase level ( J:211773 )

♂

IMPC - TCP

decreased respiratory quotient ( J:211773 )

♂

IMPC - TCP

immune system

small thymus ( J:211773 )

♂

IMPC - TCP

enlarged lymph nodes ( J:211773 )

♂

IMPC - TCP

nervous system

decreased prepulse inhibition ( J:211773 )

IMPC - TCP

Genotype
MGI:4837258

ht2

• Allelic Composition: Spop^{Gt(BGB118)Byg}/Spop⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:165268 )

N • beta cell size is normal

abnormal pancreatic islet cell apoptosis ( J:165268 )

abnormal pancreatic beta cell physiology ( J:165268 )

• beta cell replication is increased compared to in wild-type mice

• however, beta cell replication and apoptosis are balanced

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:165268 )

N • mice exhibit normal glucose homeostasis

cellular

abnormal pancreatic islet cell apoptosis ( J:165268 )

Genotype
MGI:4837259

cx3

• Allelic Composition: Pdx1^tm1Cvw/Pdx1⁺; Spop^{Gt(BGB118)Byg}/Spop⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:165268 )

N • beta cell mass and the distribution of islet size are normalized unlike in either single heterozygote

N • mice do not exhibit beta cell apoptosis unlike either single heterozygote

abnormal pancreatic beta cell morphology ( J:165268 )

• beta cell size is decreased compared to in wild-type mice or either single heterozygote

disorganized pancreatic islets ( J:165268 )

abnormal pancreatic beta cell physiology ( J:165268 )

• endoplasmic reticulum stress is reduced compared to in Pdx1^tm1Cvw heterozygote

• beta cell replication is increased compared to in wild-type mice

decreased insulin secretion ( J:165268 )

• glucose-stimulated insulin secretion is reduced compared to in wild-type mice but not as severely as in Pdx1^tm1Cvw heterozygote

homeostasis/metabolism

decreased insulin secretion ( J:165268 )

• glucose-stimulated insulin secretion is reduced compared to in wild-type mice but not as severely as in Pdx1^tm1Cvw heterozygote

increased circulating glucose level ( J:165268 )

improved glucose tolerance ( J:165268 )

• compared with Pdx1^tm1Cvw heterozygote