All Phenotypes Sema4c<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sema4c⁺
wild type
MGI:2437847

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Sema4c^tm1Matl/Sema4c⁺	B6.129P2-Sema4c^tm1Matl	MGI:4881694
cx2	Sema4c^tm1Matl/Sema4c⁺ Sema4g^tm1Kik/Sema4g⁺	B6.Cg-Sema4c^tm1Matl Sema4g^tm1Kik	MGI:4881700
cx3	Sema4c^tm1Matl/Sema4c⁺ Sema4g^tm1Kik/Sema4g^tm1Kik	B6.Cg-Sema4c^tm1Matl Sema4g^tm1Kik	MGI:4881702

Allelic Composition	Sema4c^tm1Matl/Sema4c⁺
Genetic Background	B6.129P2-Sema4c^tm1Matl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4c^tm1Matl mutation (0 available); any Sema4c mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar granule layer morphology ( J:167973 )

• 20% of mice exhibit gaps in the granule layer of lobule II unlike wild-type mice

ectopic cerebellar granule cells ( J:167973 )

• 10% of mice exhibit ectopic granule cells in the molecular layer at subpilial positions unlike wild-type mice

abnormal cerebellum lobule morphology ( J:167973 )

• 27% of mice exhibit rostral lobules VIII and IX fusion unlike in wild-type mice

Allelic Composition	Sema4c^tm1Matl/Sema4c⁺ Sema4g^tm1Kik/Sema4g⁺
Genetic Background	B6.Cg-Sema4c^tm1Matl Sema4g^tm1Kik

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema4c^tm1Matl mutation (0 available); any Sema4c mutation (36 available)
Sema4g^tm1Kik mutation (0 available); any Sema4g mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar granule layer morphology ( J:167973 )

• 40% of mice exhibit gaps in the granule layer of lobule II unlike wild-type mice

ectopic cerebellar granule cells ( J:167973 )

• 40% of mice exhibit ectopic granule cells in the molecular layer at subpilial positions unlike wild-type mice

abnormal cerebellum lobule morphology ( J:167973 )

• 69% of mice exhibit rostral lobules VIII and IX fusion unlike in wild-type mice

Allelic Composition	Sema4c^tm1Matl/Sema4c⁺ Sema4g^tm1Kik/Sema4g^tm1Kik
Genetic Background	B6.Cg-Sema4c^tm1Matl Sema4g^tm1Kik

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar granule layer morphology ( J:167973 )

• 50% of mice exhibit gaps in the granule layer of lobule II unlike wild-type mice

ectopic cerebellar granule cells ( J:167973 )

• 60% of mice exhibit ectopic granule cells in the molecular layer at subpilial positions unlike wild-type mice

abnormal cerebellum lobule morphology ( J:167973 )

• 69% of mice exhibit rostral lobules VIII and IX fusion unlike in wild-type mice

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