All Phenotypes Hic1<+> MGI Mouse

increased metastatic potential ( J:81448 )

• lymphomas and carcinomas in heterozygous mice spread rapidly to other organs, while in a control mouse, the tumor remained localized to the lung

increased lymphoma incidence ( J:81448 )

• 33% of female heterozygotes develop lymphomas and sarcomas

• males do not develop lymphomas or sarcomas at an incidence greater than controls

increased malignant tumor incidence ( J:81448 )

• heterozygotes show a predisposition to malignant tumors after 70 weeks of age

• at 70 weeks of age the incidence is 16.4 percent and none in controls; by 100 weeks of age, 32.4 percent of mice develop tumors, and the incidence in controls is 14.3 percent

• 44% of the malignant tumors are epithelial cancers

increased carcinoma incidence ( J:81448 )

• 22% of heterozygous males develop epithelial tumors, including squamous cells carcinomas of the oral cavity and ear canal, lung adenocarcinomas, hepatocellular carcinomas and pancreatic islet cell carcinoma; controls developed none

• female heterozygotes do not develop carcinomas at an incidence greater than controls

increased pancreatic islet cell carcinoma incidence ( J:81448 )

increased hepatocellular carcinoma incidence ( J:81448 )

increased lung adenocarcinoma incidence ( J:81448 )

increased squamous cell carcinoma incidence ( J:81448 )

• observed in the oral cavity and ear canal

increased sarcoma incidence ( J:81448 )